- Docente: Francesco Alviano
- Crediti formativi: 3
- SSD: BIO/17
- Lingua di insegnamento: Inglese
- Modalità didattica: Convenzionale - Lezioni in presenza
- Campus: Bologna
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Corso:
Laurea Magistrale in
Pharmaceutical biotechnology (cod. 9068)
Valido anche per Laurea Magistrale in Pharmaceutical biotechnology (cod. 9068)
Conoscenze e abilità da conseguire
Alla fine del corso lo studente conosce: - i percorsi molecolari che controllano il grado di staminalità e il potenziale di differenziazione delle cellule staminali; - gli elementi chiave riguardanti le innovazioni e lo sviluppo dei sistemi di cultura 3D per la scoperta di farmaci e il loro uso per la modellizzazione della malattia; - i metodi per la preparazione in vitro di modelli cellulari utili per la definizione di colture sferoidali 3D.
Contenuti
Frontal lessons (2 UC)
Pluripotent stem cells. Embryonic stem cells: phenotypic characterization and therapeutic potential.
Somatic nuclear transfer for the generation of pluripotent cells. Reprogrammng strategies for generation of induced pluripotetn stem cells (iPSCs).
Adult stem cells: phenotypic characterization, multipotential ability and comparison with Pluripotent Stem Cells.
Extraembryonic Tissues as sources of Perinatal Stem Cells: phenotypic characterization and biologial features.
3D Scaffold application in cell culture and organoid models: tissue engineering approach for disease modelling and regenerative medicine approaches.
3D organoid development and growh: general overview of the background and current methods for the generation and characterization of organoids
Application of human derived organoids: cerebral, liver, skin and intestinal model of organoids.
Lab work experience (1 UC)
Introduction to the lab work of the stem cell course; macroscopic description of the placenta and extraembryonic tissues; laboratory experience: isolation of human mesenchymal cells derived from fetal membranes.
Laboratory experience: isolation of human epithelial cells derived from amniotic membrane and preparation of 3D cellular models for 3D culture system.
Laboratory experience: Morphological evaluation of the cell cultures obtained and discussion of research findings.
Testi/Bibliografia
Recommended Textbook: G.P. Bagnara, Stem Cells, Ed. Esculapio.
Recommended scientific papers given during the lessons.
Metodi didattici
Frontal lectures and Laboratory work experience in Cell Culture Lab.
Modalità di verifica e valutazione dell'apprendimento
The final test focuses on the achievement of learning objectives about:
- stem cell basics and classification
- stem cell applications, cell therapy and tissue engineering
- 3D organoid l research and techniques
Oral examination on two topics among a list of topics covered during the course.
The online registration to the examination is mandatory.
Strumenti a supporto della didattica
PowerPoint presentations will be available online as downloadable content.
Orario di ricevimento
Consulta il sito web di Francesco Alviano