- Docente: Valerio Carelli
- Crediti formativi: 4
- SSD: MED/26
- Lingua di insegnamento: Inglese
- Moduli: Valerio Carelli (Modulo 1) Piero Parchi (Modulo 2)
- Modalità didattica: Convenzionale - Lezioni in presenza (Modulo 1) Convenzionale - Lezioni in presenza (Modulo 2)
- Campus: Bologna
- Corso: Laurea Magistrale in Medical biotechnology (cod. 9081)
Conoscenze e abilità da conseguire
Define the bio-molecular bases of neuronal physiology with particular reference to protein and mitochondrial metabolism Discuss the molecular and cellular etiopathogenesis of the main neurodegenerative, autoimmune and mitochondrial encephalopathies Describe examples of molecular-phenotypic correlations in the field of neurodegenerative diseases Critically evaluate the main molecular and biochemical techniques for the in vivo and post-mortem diagnosis of both genetic and sporadic diseases of the nervous system Apply molecular biology techniques to the study of neurological problems.
Contenuti
Module A – course content (Prof. Valerio Carelli)
Introductory concepts to cell pathological mechanisms leading to neurodegeneration: from cell energetic metabolism to oxidative stress, quality control of organelles and cell death pathways
Mitochondrial diseases as models of neurodegeneration:
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Heteroplasmic mtDNA mutations: the case of MELAS syndrome
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Mitochondrial optic neuropathies: how two genomes may kill retinal ganglion cells
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Mitochondrial pathogenesis of Parkinsonism
Circadian dysfunction and neurodegeneration
Cell and animal models
Therapeutic strategies
Module B – course content (Prof. Piero Parchi)
Introduction to Neurodegenerative Diseases: Basic concepts of protein folding and misfolding, amyloid formation, cell to cell prion-like transmission, prion strains
Molecular pathology and phenotypic spectrum of major neurodegenerative disorders:
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Prion diseases
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Alzheimer’s disease
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Parkinson’s disease and other synucleinopathies
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Frontotemporal dementia spectrum
Biofluid diagnostic and prognostic biomarkers in neurology
Pathogenesis and phenotypic expression of major autoimmune neurological disorders with secondary neurodegeneration (multiple sclerosis, paraneoplastic and antibody-mediated encephalitis, narcolepsy)
Testi/Bibliografia
Slide presentations and suggested reviews
Metodi didattici
Teaching lectures
Modalità di verifica e valutazione dell'apprendimento
The exam consists of an oral interview with specific questions on at least two topics.
Strumenti a supporto della didattica
Power point slides
Orario di ricevimento
Consulta il sito web di Valerio Carelli
Consulta il sito web di Piero Parchi