- Docente: Giorgio Milazzo
- Crediti formativi: 3
- SSD: BIO/18
- Lingua di insegnamento: Inglese
- Modalità didattica: Convenzionale - Lezioni in presenza
- Campus: Rimini
- Corso: Laurea Magistrale a Ciclo Unico in Pharmacy (cod. 5987)
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dal 03/10/2023 al 06/12/2023
Conoscenze e abilità da conseguire
Al termine del corso, lo studente possiede una conoscenza profonda circa i principi fondamentali dell'ereditarietà. Ha familiarità con la natura, trasmissione, espressione variabilità e manipolazione del materiale ereditario ed è in grado di comprendere, interpretare e valutare criticamente in modo rigoroso i dati sperimentali genetici.
Contenuti
- Introduction to genetics
- Mendelian Genetics
- Gregor Mendel and basic principles of heredity; monohybrid crosses (dominance and segregation); dihybrid crosses (independent assortment)
- Predicting the outcome of genetic crosses; probability and Chi-Square test
- Cell division, mitosis and meiosis, chromosomal basis of inheritance
- Sexual reproduction, mitosis and meiosis.Chromosome theory of inheritance
- Sex determination and sex-linked inheritance
- Dosage compensation in mammals
- Human pedigree analysis
- Extensions and modifications of basic mendelian principles
- Allelic variation and gene function; why some alleles are dominant and other recessive; types of dominance, reduced penetrance, lethal alleles.
- Genetic heterogeneity, gene interactions and epistasis.
- Linkage, recombination, gene mapping in Eukaryotes
- Linked genes and crossing over; Constructing genetic maps with recombination frequencies
- Linkage analysis in human; DNA polymorphisms as genetic markers; the lod-score method
- Overview of genetics of bacterial and viral genetic systems
- Genetic variation, DNA repair and recombination
- Genetic variability; mutation and polymorphisms; types of genetic variants; molecular basis of mutations; point mutations and their consequences; mutagenesis
- DNA repair mechanisms; DNA recombination mechanisms
- Variation in chromosome number and structure; mechanisms of structural variation
Testi/Bibliografia
Leland Hartwell, Michael L. Goldberg, Janice Fischer and Leroy Hood
6th edition
McGrawHill Education
Other textbooks:
Introduction to Genetic Analysis, by Griffiths, Wessler, Carroll, and Doebley.
Principles of Genetics , by D. Peter Snustad, Michael J. Simmons
Genetics. Analysis & Principles, by Robert J.Brooker
Concepts of Genetics, by Klug, Cummings, Spencer
Metodi didattici
Lectures with powerpoint presentations; in class problem solving and exercise
Modalità di verifica e valutazione dell'apprendimento
Final written and oral exam. Written will include multiple choice questions.
Strumenti a supporto della didattica
Course materials (ppt presentations, problems and solutions, suggested readings) will be made available to students by using "VIRTUALE" online platform.
Orario di ricevimento
Consulta il sito web di Giorgio Milazzo