- Docente: Piero Parchi
- Crediti formativi: 4
- SSD: MED/26
- Lingua di insegnamento: Inglese
- Modalità didattica: Convenzionale - Lezioni in presenza
- Campus: Bologna
- Corso: Laurea Magistrale in Medical Biotechnology (cod. 9081)
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dal 06/10/2023 al 05/12/2023
Conoscenze e abilità da conseguire
Define the bio-molecular bases of neuronal physiology with particular reference to protein and mitochondrial metabolism Discuss the molecular and cellular etiopathogenesis of the main neurodegenerative, autoimmune and mitochondrial encephalopathies Describe examples of molecular-phenotypic correlations in the field of neurodegenerative diseases Critically evaluate the main molecular and biochemical techniques for the in vivo and post-mortem diagnosis of both genetic and sporadic diseases of the nervous system Apply molecular biology techniques to the study of neurological problems.
Contenuti
Introduction to Neurodegenerative Diseases: Basic concepts of protein folding and misfolding, amyloid formation, cell to cell prion-like transmission, prion strains
Molecular pathology and phenotypic spectrum of major neurodegenerative disorders:
- Prion diseases
- Alzheimer’s disease
- Parkinson’s disease and other alpha-synucleinopathies
- Frontotemporal dementia spectrum
- Biofluid diagnostic and prognostic biomarkers in neurology
- Pathogenesis and phenotypic expression of the major autoimmune neurological disorders with secondary neurodegeneration (multiple sclerosis, paraneoplastic and antibody-mediated encephalitis, narcolepsy).
- Mitochondrial diseases affecting the neuro muscular system:
- Heteroplasmic mtDNA mutations: the case of MELAS syndrome
- Mitochondrial optic neuropathies: how two genomes may kill retinal ganglion cells
- Mitochondrial contribution of the pathogenesis of Parkinsonism
Testi/Bibliografia
Slide content and suggested reviews.
Metodi didattici
Interactive lectures. Teaching materials and slides are made available to the students via the moodle platform at least the day before the lesson. During the lessons, it is important for students to have direct access (online or off-line) to the teaching materials in order to be able to concentrate on specific contents rather than on reproducing slides.
Modalità di verifica e valutazione dell'apprendimento
The exam consists of an oral interview with specific questions on at least two topics.
Strumenti a supporto della didattica
Power point slides.
Orario di ricevimento
Consulta il sito web di Piero Parchi