- Docente: Simona Soverini
- Crediti formativi: 3
- SSD: MED/15
- Lingua di insegnamento: Inglese
- Moduli: Simona Soverini (Modulo 1) Simona Soverini (Modulo 2)
- Modalità didattica: Convenzionale - Lezioni in presenza (Modulo 1) Convenzionale - Lezioni in presenza (Modulo 2)
- Campus: Bologna
- Corso: Laurea Magistrale in Medical Biotechnology (cod. 9081)
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Orario delle lezioni (Modulo 1)
dal 05/03/2024 al 14/05/2024
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Orario delle lezioni (Modulo 2)
dal 14/03/2024 al 27/03/2024
Conoscenze e abilità da conseguire
Describe the biological properties of the hematopoietic stem cells and relevant biotechnological applications. Describe the phenotype and genotype of hematological malignancies. Discuss the principles of targeted therapy and cell therapy with particular reference to the transplantation of stem cells and regenerative medicine. Define the molecular targets and cellular structures suitable for the development of new forms of targeted therapy. Critically evaluate new diagnostic and therapeutic approaches in hematology.
Contenuti
Hematopoiesis.
Normal and leukemic stem cells and their niche.
Mechanisms of leukemogenesis.
Molecular bases of acute leukemias.
Molecular bases of chronic myeloproliferative diseases.
Principles of targeted therapy.
Mechanisms of resistance to target therapy.
Molecular diagnosis and monitoring of therapeutic response in leukemias.
Testi/Bibliografia
"Hematology-Pathophysiology, Diagnosis and Treatment" S. Tura, M. Cavo, PL. Zinzani-Società Editrice Esculapio Bologna.
In addition, specific recent bibliography and web resources will be indicated.
Metodi didattici
Power Point slide presentations
Modalità di verifica e valutazione dell'apprendimento
Oral exam at the end of the course, upon registration.
The oral exam will consist of two questions.
The final exam aims to evaluate the achievement of the educational objectives:
- To know the biomolecular bases of normal and leukemic hemopoiesis
- To understand the design of an experimental research plan and to critically evaluate experimental results.
The final grade of the Integrated Course is based on the average of the scores reported on topics related to the main objectives of the Course.
Strumenti a supporto della didattica
Slides and scientific literature will be made available to students.
Orario di ricevimento
Consulta il sito web di Simona Soverini