- Docente: Simona Soverini
- Credits: 3
- SSD: MED/15
- Language: English
- Moduli: Simona Soverini (Modulo 1) Simona Soverini (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Medical Biotechnology (cod. 9081)
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from Mar 05, 2024 to May 14, 2024
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from Mar 14, 2024 to Mar 27, 2024
Learning outcomes
Describe the biological properties of the hematopoietic stem cells and relevant biotechnological applications. Describe the phenotype and genotype of hematological malignancies. Discuss the principles of targeted therapy and cell therapy with particular reference to the transplantation of stem cells and regenerative medicine. Define the molecular targets and cellular structures suitable for the development of new forms of targeted therapy. Critically evaluate new diagnostic and therapeutic approaches in hematology.
Course contents
Hematopoiesis.
Normal and leukemic stem cells and their niche.
Mechanisms of leukemogenesis.
Molecular bases of acute leukemias.
Molecular bases of chronic myeloproliferative diseases.
Principles of targeted therapy.
Mechanisms of resistance to target therapy.
Molecular diagnosis and monitoring of therapeutic response in leukemias.Readings/Bibliography
"Hematology-Pathophysiology, Diagnosis and Treatment" S. Tura, M. Cavo, PL. Zinzani-Società Editrice Esculapio Bologna.
In addition, specific recent bibliography and web resources will be indicated.Teaching methods
Power Point slide presentations
Assessment methods
Oral exam at the end of the course, upon registration.
The oral exam will consist of two questions.
The final exam aims to evaluate the achievement of the educational objectives:
- To know the biomolecular bases of normal and leukemic hemopoiesis
- To understand the design of an experimental research plan and to critically evaluate experimental results.
The final grade of the Integrated Course is based on the average of the scores reported on topics related to the main objectives of the Course.
Teaching tools
Slides and scientific literature will be made available to students.
Office hours
See the website of Simona Soverini