- Docente: Mattia Lauriola
- Credits: 3
- SSD: BIO/17
- Language: English
- Moduli: Mattia Lauriola (Modulo 1) Pasquale Marrazzo (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Medical Biotechnology (cod. 9081)
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from Apr 30, 2024 to May 30, 2024
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from May 08, 2024 to May 24, 2024
Learning outcomes
Describe the mechanisms that control embryogenesis and morphogenesis in relation to human abnormalities and malformations. Discuss the mechanisms underlying embryonic processes focusing on recent discoveries that have shed light on traditional concepts or raised new doubts. Critically evaluate issues related to embryonic and adult stem cells. Describe the methods for stem cell isolation to obtain progenitor cells from perinatal tissues.
Course contents
Introduction to human development
- Reproductive organs
- Femal Reproductive Cycles: ovarian cycle and menstrual cycle
- Transportation of Gametes: oocyte transport and sperm transport and maturation
- Viability of oocytes and sperms
First week of human development
- Fertilization
- Phases of fertilization
- Cleavage of zygote
- Formation of Blastocyst
Second week of human development
- Formation of amniotic cavity, embryonic disc and umbilical vesicle
- Development of Chorionic Sac
- Implantation sites of Blastocystes
Third week of human development
- Gastrulation: formation of germs layers
- Neurulation: formation of the neural tube
- Development of Somites
- Development of Intraembryonic coelom
- Early development of cardiovascular system, example of regeneration
- Development of Chorionic Villi
Fourth Week of human development
- Folding of Embryo
- Head and Tail Folds
- Lateral Folds
- Germ Layer Derivatives
- Control of Embryonic Development
- Estimation of Embryonic Age
Placenta and fetal membranes
- Decidua
- Development of Placenta
- Fetomaternal junction
- Intervillous Space
- Amniochorionic Membrane
- Placental Circulation
- Stages of Labor
- Placenta and Fetal Membranes after Birth
- Umbelical Cord
- Amnion and amniotic fluid
- Umbelical vesicle
- Fetal Membranes
Principles and Mechanisms of Morphogenesis
- Animal models
- Patterning the vertebrate embryo
- Oogenesis, embryonic development, and offspring from female iPSC-derived PGCLCs.
- Self-Organization of the in vitro attached human embryo
- Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis
Readings/Bibliography
Human Embryology and Developmental Biology
Bruce Carlson, Elsevier
Before we are Born, Essential of Embryology and Birth Defects
Keith.L. Moore, T.V.N. Persaud, Mark G. Torchia. Elsevier
Articles provided during the frontal lessons
Teaching methods
A combination of frontal lessons and lessons inter-pares on specific topics. The acquisition of the knowledge will be frequently monitored with discussion test
Assessment methods
The students will be evaluated by oral exam.
Teaching tools
Power-Point presentations and interactive use of dedicated websites
Office hours
See the website of Mattia Lauriola
See the website of Pasquale Marrazzo