00768 - General Pathology

Learning outcomes

At the end of the course the student has expertise relating to: fundamental principles of the etiology and pathogenesis, cellular and tissue changes leading to reversible and irreversible damage, the molecular and cellular bases of acute, chronic and repair inflammatory response, the specific mechanisms of the adaptive immunity, its defensive aspects and possible pathological consequences; the etiopathogenesis of neoplastic transformation, progression to malignancy and metastasis.

Course contents

INTRODUCTION AND FUNDAMENTAL CELLULAR PATHOLOGY

• Objectives, purpose and organization of the course.
• Etiology and pathogenesis, classification of etiologic factors.
• Cell injury : subletal alterations, apoptosis and necrosis.
• Cell ageing
• Cell adaptation : atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia.
  

DEFENSE MECHANISMS

• Innate immunity
• Adaptive immunity
• Acute and chronic inflammation
• Systemic responses and fever.
• Repair, regeneration and healing
• Immunopathology
• Transplants
• Vaccines

TUMOR BIOLOGY

• Benign and malignant tumors, nomenclature.
• Cancer epidemiology.
• Cancer genes: oncogenes and tumor suppressor genes.
• Inherited tumors.
• Cancer progression and malignant phenotype.
• Metastatic process.
• Immune response and cancer antigens.
• Chemical, physisical and infectious carcinogenic agents.

Readings/Bibliography

 PONTIERI, Elementi di Patologia Generale, 4a edizione, PICCIN 2018

Regueiro Gonzalez e coll.- Immunologia. Biologia e patologia del sistema immunitario., PICCIN 2011

Teaching methods

Lectures
Interactive summaries

Assessment methods

Written tests, administered in itinere and consisting of both multiple choice and open questions, and oral exams will evaluate the achievement of learning objectives:

- knowledge of fundamental principles of the etiology and pathogenesis

- knowledge of molecular and cellular bases of acute, chronic and repair inflammatory response,

- knowledge of mechanisms of innate and adaptive immunity

- knowledge of the etiopathogenesis of neoplastic transformation, progression to malignancy and metastasis.

In itinere tests and/or oral exam will contribute to the final mark of the Integrated Course 39275 PATOLOGIA GENERALE, GENETICA MEDICA E ONCOLOGIA MEDICA, with proportion to the number o credits assigned to General Pathology

Teaching tools

Video projector, PC

Didactic material showed in lectures can be downloaded by students from e-learning website (login with student credentials). Students are invited to attend lectures bringing a printed copy of didactic materials.

Office hours

See the website of Carla De Giovanni