11438 - Drug Analysis II (GR.A)

Learning outcomes

The student will learn to identify pharmaceutical compounds through chemical reactions and instrumental methods (chromatography and spectrometry).

Course contents

Functional groups: physical, spectroscopic and chemical properties.
Methods of analysis for the identification of drugs: characters, solubility, elemental analysis, boiling point, melting point, density, refractive index, optical rotation, infrared spectrometry (IR), nuclear magnetic resonance spectrometry (NMR). Spectra-structure relationship.
Methods of purification and separation: crystallitation, distillation.

The lessons are supplied by individual practical laboratory classes with final examination

Readings/Bibliography

1. Laboratory duplicated lecture notes: practical part.

2. V. Cavrini, V. Andrisano, Principi di Analisi Farmaceutica, Esculapio, 2013.

3. F. Savelli, O. Bruno, Analisi Chimico Farmaceutica. Elementi di Analisi Qualitativa e Metodi Applicati ai Farmaci della European Pharmacopoeia, Piccin 2005.

 

Teaching methods

32 hours of theoric lectures (October - January) and 36 laboratory practice in single work bench (12 – 13 consecutive afternoons) in presence of the same lecturer

Assessment methods

The final examination aims to evaluate the achievement of didactic targets:

- to know and to be able to apply practically the identification reactions of functional groups of organic and metal-organic drugs;

- to know and to be able to apply practically the identification reactions of inorganic, metal-organic and organic drugs;

- to know the main instrumental techniques to identify the drugs and to be able to apply practically instrumental techniques such as IR, optical rotation and melting point,

- to demonstrate of being able to learn the main topics of the course, dealing with the next teachings.

Practical test (unlimited validity) consists in the identification of two drugs of European Pharmacopoeia and is propaedeutic to oral examination. To pass the oral examination, it will be required the knowledge of at least three main topics reported in the program.

Teaching tools

Farmacopea Ufficiale Italiana (FU)

European Pharmacopeia (Eur. Pharm.)

Laboratory practice

Office hours

See the website of Rita Gatti