57359 - Analysis of Medicines I (GR-B)

Learning outcomes

The subject of the course is quantitative analysis applied in the pharmaceutical field, performed through the use of analytical chemical methods. It provides the theoretical and practical basis that is fundamental for the main techniques used in measurement of inorganic substances of pharmaceutical interest. The course sets out to provide students with professional training in the basic theoretical notions of pharmaceutical quantitative inorganic analysis, allowing their verification and understanding in individual experimental work in the laboratory. Through the knowledge and use of volumetric analytical methodologies, students acquire skill, experience and manual approaches necessary for the correct solution of diverse analytical problems, such as the determination of the content or purity of inorganic compounds. At the end of the course, which will include laboratory exercises in a single place, the student will possess knowledge of methods of quantitative volumetric analysis reported in the monographs of the European Pharmacopoeia (E.Ph.) and the Italian Official Pharmacopoeia (FUI) for the determination of the quantity and purity of active inorganic substances. In particular, the student is able to apply his knowledge to real problems (unknowns quantitative analysis and their quality control).

Course contents

Modulo of "Qualitative Analysis"
Introduction to pharmaceutical analysis. Qualitative methods of analysis. Measurement methods and preliminary operations in chemical analysis. Italian Pharmacopoeia (FU) and European Pharmacopoeia. Ions of pharmaceutical and toxicological interest: properties, identification reactions, pharmacological and toxicological activity (ammonium salts, silver, lead, mercury, arsenic, antimony, copper, bismuth, iron, aluminium, zinc, manganese, cobalt, calcium, barium, magnesium, sodium, potassium, lithium, sulphates, nitrates, phosphates, borates, chlorides, bromides, iodides, carbonates, acetates).
Amphoterism. Complex ions; structure of complex ions. Stability and importance of complex ions in analysis. Chelates. Oxidation-reduction reactions.
The colloidal state.
Introduction to spectroscopic analysis: flame atomic emission spectroscopy.
Limit tests of impurities of inorganic compounds of FU.
Laboratory lessons: identification reaction of ions, limit tests of impurities. Identification and tests of inorganic compounds of FU.

 

Modulo of  "Quantitative Analysis"

The teaching syllabus comprises a theoretical part, which imparts a knowledge of the analytical techniques for quantitative assay and purity determination of inorganic substances of pharmaceutical interest followed by an applied part, during which the notions learnt are put into practice. After an introduction to the basic aspects of applied chemical analysis in the pharmaceutical field and some remarks on the fundamental principles of quantitative analysis, the theoretic teaching deals with the chemical methods of pharmaceutical analysis. The former include volumetric analyses realized by precipitimetric, redox, complexometric and neutralization titrations.

Readings/Bibliography

Module of "Qualitative Analysis"

It is not necessary to purchase specific texts. The teaching material is available through username and password at AMS Campus -AlmaDL - University of Bologna. For deepening, recommended texts are:

-  A. Araneo.  Chimica Analitica Qualitativa

-  P. Barbetti M. G. Quaglia.  L'Analisi qualitativa in chimica farmaceutica e tossicologica inorganica

 

Module of "Quantitative Analysis"

It is not necessary to purchase specific texts. The teaching material is available through username and password at AMS Campus -AlmaDL - University of Bologna. For deepening, recommended texts are:

-  Hage, D.S., Carr, J.D. “Chimica Analitica e Analisi Quantitativa”, Piccin, 2012

-  Porretta, G.C. “Analisi di preparazioni farmaceutiche -Analisi quantitativa”, Vol. I e II, Ed. CISU, 2000

-  Abignente, E., Melisi, D., Rimoli, M.G. “Principi di Analisi Quantitativa dei Medicinali”, 2a Edizione, Vol. I, II e III, Ed. Loghia, 2011

-  Pantry "Guide to the practical exercises of Quantitative Analysis" (available 'on line' in the web page of the teacher and the two copy-shops in Via San Donato, in front of the Bodoniana building)

·   Copy of the Slides Lecture (available 'on line' to the teacher's web page)

Teaching methods

Module of "Qualitative Analysis"

The teaching module consists of theoretical lessons (32 hours), held by the responsible teacher from October to January, and individual practical work in a chemical laboratory (36 hours ), supervised by the same teacher, distributed among 12 consecutive afternoons in the period from March to June.

 

Module of "Quantitative Analysis"

The teaching module consists of theoretical lessons (32 hours), held by the responsible teacher from October to January, and individual practical work in a chemical laboratory (36 hours ), supervised by the same teacher, distributed among 12 consecutive afternoons in the period from March to June.

Assessment methods

Module of  "Qualitative Analysis" and  Module of "Quantitative Analysis"

The assessment of the learning tends to ensure the achievement of the teaching objectives of course:
- knowledge of the chemical methods of qualitative and quantitative analysis;

- ability to apply theoretical and practical knowledge gained to the recognition and dosage of inorganic substances of pharmaceutical interest;

- ability to interpret and use the analytical methods reported in the Italian Official Pharmacopoeia and European Pharmacopoeia in order to identify compounds of pharmaceutical interest, of inorganic structure, and verify their purity.

This verification is carried out by means of laboratory practice test, organized at the end of the practical exercises of each individual module, and the final oral examination, with one overall judgment for the two modules. The practice final test, of unlimited validity, is a prerequisite necessary to access the oral examination. Preliminary registration in the AlmaEsami list is required for the access to oral examination. The students, of which the Council of Studies Course validates the signature frequency acquired in previous career, they must pass the laboratory practice test before the oral exam.

Teaching tools

Module of "Qualitative Analysis"

Teacher's written lesson notes, Italian and European Pharmacopoeia.

Lesson slides: available at http://campus.unibo.it/

Laboratory handouts: available at the copy shops in Via S. Donato.

Username and password are reserved for students enrolled at the University of Bologna.

 

Module of "Quantitative Analysis"

The teaching material presented in class (slides, teaching program, program and schedule of laboratory exercises) and that which is necessary to exercises in single seat (laboratory hand outs) will be made available to the student in electronic format via the Internet. Such material should be printed and brought to the lessons and the laboratory exercises.

Italian and European Official Pharmacopoeia.

To get teaching material: http://campus.unibo.it/

Username and password are reserved for students enrolled at the University of Bologna.

Links to further information

http://www.unibo.it/SitoWebDocente/default.htm?UPN=nadia.ghedini%40unibo.it

Office hours

See the website of Laura Garuti

See the website of Michela Rosini