- Docente: Giuseppe Gasparre
- Credits: 1
- SSD: MED/03
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 8415)
Learning outcomes
Course contents
- Mitochondrial DNA: structure,
replication, transcription and translation. Mitochondrial
genetics.
- Aerobic glycolysis vs. respiration: the metabolism of solid
neoplasms.
- Metabolic tumor suppressor genes and relevance in cancer
progression.
- Mitochondrial DNA mutations within tumor genesis and cancer
progression.
- Oncocytic neoplasias: the importance of mitochondrial
metabolism in cancer.
Readings/Bibliography
Mitochondria and cancer. Wallace DC. Nat Rev Cancer. 2012 Oct;12(10):685-98. doi: 10.1038/nrc3365.
Mitochondrial mutations in cancer. Brandon M, Baldi P, Wallace DC. Oncogene. 2006 Aug 7;25(34):4647-62. Review.
Mitochondria and cancer: Warburg addressed. Wallace DC. Cold Spring Harb Symp Quant Biol. 2005;70:363-74. Review.
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Wallace DC. Annu Rev Genet. 2005;39:359-407. Review.
Complex I impairment in mitochondrial diseases and cancer: Parallel roads leading to different outcomes. Iommarini L, et al. Int J Biochem Cell Biol. 2012 Jun 2.
Learning from oncocytic tumors: Why choose inefficient mitochondria? Gasparre G, et al. Biochim Biophys Acta. 2011 Jun;1807(6):633-42. Epub 2010 Aug 21. Review.
A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells.Icard P, Lincet H. Biochim Biophys Acta. 2012 Dec;1826(12):423-33. doi: 10.1016/j.bbcan.2012.07.001.
Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA. Pohjoismäki JL, Goffart S. Bioessays. 2011 Apr;33(4):290-9. doi:10.1002/bies.201000137. Epub 2011 Feb 2.
Mitochondrial DNA transcription regulation and nucleoid organization. Rebelo AP, Dillon LM, Moraes CT. J Inherit Metab Dis. 2011 Aug;34(4):941-51. Epub 2011 May 4. Review.
Teaching methods
Lectures
Assessment methods
Multiple choice test
Teaching tools
Powerpoint slides
Scientific papers
Office hours
See the website of Giuseppe Gasparre