Abstract
The InBLOOM project investigates the role of the blood microbiome in colorectal cancer (CRC) etiology and detection. Based on a case-control study including 100 CRC patients, 100 with intestinal adenomas and 100 healthy controls, the project builds on preliminary 16S rRNA analyses and detailed lifestyle and dietary data. Using shotgun metagenomics, InBLOOM will characterize the taxonomy, function, and origin of circulating microbial DNA in blood. Multivariate models will link blood microbiome features to CRC risk, identify potential diagnostic biomarkers, and assess associations with lifestyle factors. This innovative approach aims to clarify the microbial contribution to the adenoma–carcinoma sequence and improve CRC prevention strategies.
Dettagli del progetto
Responsabile scientifico: Simone Rampelli
Strutture Unibo coinvolte:
Dipartimento di Farmacia e Biotecnologie
Coordinatore:
ALMA MATER STUDIORUM - Università di Bologna(Italy)
Contributo totale di progetto: Euro (EUR) 229.208,00
Contributo totale Unibo: Euro (EUR) 129.314,00
Durata del progetto in mesi: 24
Data di inizio
30/11/2023
Data di fine:
28/02/2026
