Shedding new light on the Possible mechAnisms underlying broiler CHickens abnormalities: Gallus gallus as animal model for colLagen type 4-related muscle disorders (PACHOL4)

PRIN 2022 Soglia

Abstract

In the past decade, a group of growth-related abnormalities affecting the Pectoralis major muscles of fast-growing broiler chickens selected for meat production purposes has abruptly emerged all over the World with impressive incidence levels and severity. These spontaneous defects, known as White Striping (WS) and Wooden Breast (WB) often coexist, manifest with distinctive phenotypes, and exhibit peculiar histological features which resemble those associated to myopathic conditions in humans. This proposal, built on a recently formulated hypothesis, aims at evaluating whether an intracellular accumulation and/or an altered extracellular arrangement of COL4 may represent the primary cause underlying the occurrence of growth-related defects.

Dettagli del progetto

Responsabile scientifico: Francesca Soglia

Strutture Unibo coinvolte:
Dipartimento di Scienze e Tecnologie Agro-Alimentari

Coordinatore:
ALMA MATER STUDIORUM - Università di Bologna(Italy)

Contributo totale di progetto: Euro (EUR) 206.752,00
Contributo totale Unibo: Euro (EUR) 133.160,00
Durata del progetto in mesi: 24
Data di inizio 12/10/2023
Data di fine: 31/01/2026

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