98672 - CRYSTAL ENGINEERING

Conoscenze e abilità da conseguire

At the end of the course the student has acquired knowledge to design, prepare and characterize crystalline molecular materials and coordination networks and to study crystal polymorphs and co-crystals.

Contenuti

1. Introduction. Hystorical background. When crystal engineering was born. Tutorials on most relevant techniques for the investigation of the solid state (IR and RAMAN spectroscopies, solid state NMR, X-ray diffraction, differential scanning calorimetry, TGA) 

2. Intermolecular interactions in molecular crystals, amorphous substances, hydrogen bonds, halogen bonds, sigma-hole interactions, coordination bonds to construct superstructures.

3. Crystal forms. Multeplicity of crystal forms for a same substance, crystal polymorphism, hydrates, solvates, salts, co-crystals and their polymorphs

4. Crystal Polymorphism. The issue of identification, characterization, usage of crystal forms. The impact in the pharmaceutical field. Aspects related to intellectual property issues. Enantiotropic and monotropic polymorphism. Case studies.

5. Crystallization. Main techniques. From solution, from melt, The kinetic problem and the quest for the most thermodynamically stable form.

6. Solvates and hydrates. Dynamic vapour sorption. Solubility and stability of hydrates. The formation of solvates and hydrates via crystallization. Solvent removal and interconversion. Thermodynamic and calorimetric aspects. Case studies.The case of rifaximin.

7. Co-crystals. Preparation of multicomponent molecular crystals, the problem of acid-base crystals, proton transfer. mechanochemical prep. Aspects related to IP issues and patentability. The ionic co-crystals. Case studies.

 8. Chirality. Chiral crystals, relationship between chirality at the molecular level and at crystal level. Racemic mixtures, racemic conglomerates, racemates. The importance of chiral resolution. Case studies.

9. Metal Organic Frameworks. Hystorical background: the relationship between coordination chemistry and coordination networks: spacers and knots. Case studies. The properties of MOF. Their industrial utilization: gas storage, catalysis in nanocavities, molecular sieves. Adsorption and desadsorption of molecules in/from MOF.

10. HOFs. Organic hydrogen bonded networks. Preparation and applications as porous materials.

Lab experiences on

i) polymorphic transitions (DSC, Xray powder diffraction)

ii) dehydration of hydrates (TGA, DSC, Xray diffration)

iii) co-crystal design and preparation (database analysis, crystallization, characterization)

iv) coordination polymer / MOF preparation (characterization)

Activities in the chemical laboratory are planned. To attend the practical part students are required to attend Module 1 and 2 in e- learning mode [https://www.unibo.it/it/servizi-e-opportunita/salute-e-assistenza/salute-e-sicurezza/sicurezza-e-salute-nei-luoghi-di-studio-e-tirocinio] and a Module 3 about health and safety in study places. Information about the dates and modes to attend module 3 will be published on the Degree Course website.

Testi/Bibliografia

Crystal Engineering. Lectures notes by Fabrizia Grepioni and Dario Braga. Available on line from UniBo web site

Crystal Engineering. A textbook. Gautam Desiraju, Jagadese Vittal, Arunachalam Ramanan. World Scientific Publishing

power point presentations provided by the teacher.

Metodi didattici

lectures deliverd by prof. Braga and seminars provided by visiting guest professors of the course on specific topic

Modalità di verifica e valutazione dell'apprendimento

oral examination and evalutation of written report on the practical lab experiences

Strumenti a supporto della didattica

power point presentations and videos from the web

Orario di ricevimento

Consulta il sito web di Dario Braga