Porous hierarchical scaffold for the replacement, repair, regeneration, reconstruction and/or simulation of a bone tissue, in particular of the trabecular and/or cortical bone tissue.
| Patent title | Hierarchical scaffold for the regeneration and/or simulation and/or replacement of a bone tissue |
|---|---|
| Thematic area | Health |
| Ownership | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA |
| Inventors | Alberto Sensini, Maria Letizia Focarete, Luca Cristofolini, Andrea Zucchelli, Chiara Gualandi |
| Protection | Italy (opportunity for seeking patent protection internationally) |
| Licensing status | Available for development agreements, option, license and other exploitation agreements |
| Keywords | Electrospinning, Hierarchical structures, Electrospun bone scaffold, Electrospun cartilage scaffold |
| Filed on | 07 August 2020 |
In tissue engineering, the use of three-dimensional and biomimetic scaffolds for regeneration and replacement of damage tissues is a known and effective strategy. These scaffolds must have specific morphological characteristics (e.g., internal porosity) in order to allow the regeneration of bone tissue.
The invention regards a process for the preparation of a porous hierarchical scaffold used for the replacement, repair, regeneration, reconstruction and/or simulation of a bone tissue. This scaffold is able to accurately reproduce the morphological, physiological and mechanical characteristics of connective tissues, such as bones. Our innovative support is characterized by a sacrificial porous sheath consisting of nanofibers. After the integration, the sacrificial scaffold is removed so as to obtain a porous scaffold having internal pores according to the cellular matrix of bone tissue.
Innovative biomimetic scaffold that allows to accurately reproduce the morphological, physiological and mechanical characteristics of connective tissues.
Application:
- Veterinary and human surgery,
- In-vitro testing,
- Actuators and robotics,
- Sensors.