The invention is a method for the diagnosis of a Peripheral T-Cell Lymphoma (PTCL) and subtypes through the use of a molecular signature.
| Patent title | Method and diagnostic kit for identification of PTCL subtypes |
|---|---|
| Thematic area | Health |
| Ownership | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA |
| Inventors | Maria Antonella Laginestra, Fabio Fuligni, Pier Paolo Piccaluga, Maura Rossi, Stefano Pileri |
| Protection | Italy |
| Licensing status | Available for development agreements, option, license and other exploitation agreements |
| Keywords | Peripheral T-Cell Lymphoma (PTCL), gene expression profile, molecular signature, diagnostics, differential diagnosis |
| Filed on | 19 December 2014 |
Peripheral T-cell lymphomas are very aggressive tumours, and their diagnosis is particularly difficult. Nevertheless, a prompt and correct diagnosis is essential for an optimal patients prognostication and treatment.
We identified the molecular signatures specific of the commonest nodal PTCLs. By testing them in a phase 4 diagnostic accuracy study developed according to the Evidence Based Medicine rules, we demonstrated their efficiency in discriminating the different tumour types.
Advantages of the Invention:
1. Improvement of the diagnostic accuracy for PTCL differential diagnosis;
2. Relatively easy tool (the algorithms necessary for the analysis are available online without costs);
3. Reproducibility and possibility of standardization among different laboratories.