84402 - CLINICAL IMMUNOLOGY

Conoscenze e abilità da conseguire

Describe the clinical manifestations, etiology, epidemiology, risk factors, natural history, diagnosis, staging, prognostic indicators and management of the major diseases of the immune system, with emphasis on those most commonly encountered in the clinical practice. Identify the major diagnostic and therapeutic options for each encountered clinical scenario, and discuss their benefits and limitations. Summarize decision-making algorithms for a correct differential diagnosis, prognosis, and treatment choice. Demonstrate an understanding of the overlap of immunology with other disciplines. Present and critically analyze clinical cases, discuss the differential diagnosis, and formulate appropriate diagnostic and therapeutic strategies for each case (Problem-Based Learning).

Contenuti

-General concepts of immune response. Innate vs adaptive Immunity.

-Primary immunodeficiencies (antibody deficiency, cell-mediated, phagocytosis, complement, mixed).

-Mechanisms of autoimmunity: Organ and non-organ specific autoimmunity.

-Laboratory tests for the diagnosis of immune-related diseases.

-Monogenic autoimmune diseases (autoimmune polyglandular syndromes).

-Autoinflammatory diseases (FMF, HIDS, TRAPS).

-Systemic Vasculitis.

-Antiphospholipid syndrome (APS)

-Autoimmune Liver Diseases.

-IgG4 related Disease

-Celiac disease

-Allergic diseases: generalities, chemical mediators, methods of investigation, main organ pathologies. Basis of therapy of allergic diseases.

-Main immunomodulatory and immunosuppressive therapies.

Testi/Bibliografia

Robert R Rich. Clinical immunology: principles and practice.

Chapel, Misbah, Haeney, Snowden. Essential Clinical Immunology.  

Metodi didattici

Formal lessons.

Modalità di verifica e valutazione dell'apprendimento

Oral examination

Strumenti a supporto della didattica

Additional references will be provided during the course.

Orario di ricevimento

Consulta il sito web di Alessandro Granito