- Docente: Pier Luigi Lollini
- Credits: 5
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 8415)
Learning outcomes
At the end of the course the student knows the mechanism through which genomic alterations cause diseases; the phenotype of tumor cells, the origin and natural history of tumors within the framework of cancer prevention and innovative preclinical approaches to the control of cancer; the student is able to apply this knowledge to specific pathologies.
Course contents
The following syllabus includes the entire program of the Basic
Oncology module. The integrated course also includes Immunology and
Genetic Pathology.
*Introduction, definitions and classification
*Basic Oncology and Medical Oncology
*The size of the problem
*Benign and malignant tumors
Tumors are genic diseases
*Oncogenes and tumor suppressor genes,
"gatekeepers" and "caretakers"
*Mechanisms of cancer gene
activation/inactivation and their consequences
*Therapeutic implications of oncogenes and tumor
suppressor genes
Genetic predispositions
*The neoplastic phenotype
*Growth, Differentiation, Cell
death
*Genomic instability
*Morphological and metabolic features
*Natural history
*Monoclonality, Heterogeneity
*Preneoplastic lesions
*Progression
The causes of cancer
Exogenous and endogenous carcinogens
Biological and molecular mechanisms of
physical, chemical and biological carcinogenesis
Cancer epidemiology
Primary, secondary and tertiary cancer
prevention. Chemoprevention. Immunoprevention
Tumor-host relationships
*Angiogenesis
*The metastatic process
*Paraneoplastic syndromes
Tumor immunology
Fundamentals of cancer therapy
Basis and molecular/biological mechanisms of
cancer therapy: radiation therapy, drugs, biological and
immunological agents, gene therapy
*Lectures by Prof. Patrizia Nanni
Readings/Bibliography
Note: english-speaking students can use original versions of the
books, when available.
Recommended
Robbins. Kumar & Klatt. Il manuale di patologia generale e anatomia patologica. Edra Masson
Alternative
Pontieri, Patologia generale, Piccin
Teaching methods
Lectures.
Assessment methods
The final grade takes into account the synthesis of final evaluations of different subjects belonging to the integrated course of Immunology and Molecular Pathology. Each single evaluation (performed as oral or written test as to Immunology) is integrated in order to obtain the unique final grade (maximum 30 points). Such grade is the CFU-weighted average of grades obtained in specific questions on main objectives of the integrated course (10 CFU), which consists of the following three subjects: Immunology (5 CFU), Genetic Pathology and Oncology (5 CFU). Examination is passed if the grade in each subjects is not lower than 18 points.
Teaching tools
All the slides shown during lectures can be downloaded from the Campus web site.
Office hours
See the website of Pier Luigi Lollini
SDGs
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.