- Docente: Stefano Iotti
- Credits: 3
- SSD: BIO/12
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: First cycle degree programme (L) in Biomedical Laboratory techniques (cod. 8484)
Learning outcomes
The student will achive a a detailed knowledge of the regulation of the biochemical processes in different tissues (liver, muscle, brain) together with a general overview of the main biochemical deficits generating metabolic diseases in different tissues.
Course contents
Sistematic Biochemistry
Liver. Functions and metabolic flexibility. Bile acids. Glucidic metabolism. Lipid metabolism. Protein metabolism. Detossification of xenobiotics. Protection from Oxidative damage. Ethanol metabolism.
Muscle. Contractile and regulatory proteins. Muscle contraction. Ionic channel. Calcium fluxes. Skeletal and cardiac muscle metabolism. Bioenergetics: system of energy buffers "phosphocreatine shuttle" model.
Brain. Biochemistry of the transmission of the nerve impulses. Synaptic transmission. Ectopic neurotransmission. Ephaptic coupling of cortical neurons. post-synaèptic receptors. GABA and Glutamic acid. NO and long term potentiation.
Tisuses homeostasis.
Regolatory mechanisms of tissues homeostasis. Regulation of transcription factors function. Hormones. Membrane receptors. Proteine kinases and signal transduction. G proteins.
Readings/Bibliography
Biochimica Sistematica Umana
C.M. Caldarera
CLUEB
Fondamenti di Biochimica
D. Voet
J. Voet
C. W. Pratt
ZANICHELLI
Teaching methods
frontal lessons
Assessment methods
written test with multiple choice questions
Teaching tools
Teaching material such as slides, animations, films used during lessons will be made available to studens on line. The printable material should be taken by the student to class.
The teaching material can be dowloaded at http://campus.unibo.it/
Username and password are assigned to students regularly registered at the University of Bologna
Office hours
See the website of Stefano Iotti