84923 - Pharmacology and Pharmacotherapy II

Learning outcomes

At the end of the course the student: - knows the main molecular mechanisms and the pharmacodynamic and therapeutic profile of drugs active on the central nervous system, on renal and cardiovascular functions, on respiratory and gastro-intestinal functions, on inflammation and the immune system, on blood cells and on the coagulation and aggregation of platelets, minerals and vitamins; - knows the drugs that influence endocrine functions; - is able to evaluate the effectiveness and safety of drugs and their ability to prevent and treat certain diseases or alleviate their symptoms; - knows the main adverse and side effects that can limit its use; - is able to recognize interactions between drugs; - applies the knowledge learned to carry out the profession, for the correct storage and dispensing of medicines, to inform and educate on the use of medicines; - has the knowledge that allows him to report adverse reactions to drugs; - applies the knowledge learned to carry out the profession, for the correct storage and dispensing of medicines, to inform and educate on the use of medicines and monitor the management of the appropriateness in the use of medicines and the continuity of adherence to pharmacological therapy in chronic therapies.

Course contents

MODULE I - Teacher: Santi Mario Spampinato;

Cardiovascular and renal system: Drugs for the treatment of heart failure and ischemic heart disease

Antiarrhythmics

The renin-angiotensin system

Pharmacological control of arterial hypertension

Diuretics

Anticoagulants

Thrombolytics Antiaggregants Antifribinolytics

Central nervous system: Anatomical-functional organization of the central nervous system

General anaesthetics

Antiepileptics

Pharmacological treatment of movement disorders

Antipsychotics

Antidepressants

Opioids agonists and antagonists

Pharmacological treatment of anxiety and sleep disorders

Pharmacological treatment of neurodegenerative diseases

Substances of abuse.

MODULE II - Teacher: Prof. Andrea Bedini

Hemopoietic drugs

Treatments for anemia and blood disorders

Hypolipidemic drugs

Pharmacotherapy of Asthma and COPD

Antitussive and mucolytic drugs

Antiacids and antisecretory drugs

Antiemetics and prokinetic drugs

Endocrine pharmacology

MODULE III - Teacher: Prof. Monica Baiula

Immune system and inflammation

Histamine, bradykinin and their antagonists

Autacoids, eicosanoids, PAF

NSAIDs

Glucocorticoids

Immunosuppressants and immunostimulants

Antidiarrheal and laxative drugs

 

 

Readings/Bibliography

Stefano Govoni, Salvatore Cuzzocrea, Adele Lucchelli, Pierluigi Navarra, Marco Racchi, Francesco Scaglione, Santi Mario Spampinato. Farmacologia con sito web. Casa Editrice Ambrosiana, 2014.

Testo da utilizzare per approfondimenti

Goodman & Gilman. Le basi farmacologiche della terapia. Con espansione online

Autori: Laurence L. Brunton, Randa Hilal-Dandan, Bjorn C. Knollmann

Casa editrice Zanichelli - Edizione 2019

Teaching methods

Slides are available on Virtuale.

Assessment methods

Students attending classes are allowed to take during the first semester (typically at the beginning of December) a compulsory in itinere written exam on cardiovascular and renal pharmacotherapy. This exam includes 4 open questions. If passed, this in itinere exam is valid until the following December; students who pass the in itinere exam are exempted from answering questions on cardiovascular and renal pharmacotherapy during the final written exam. 

The final exam consists of two parts:

-firstly, a 100 min long written exam made of 10 open questions;

-secondly, an oral exam for those students who passed the written exam.

Students are required to enroll for exams via AlmaEsami.

Teaching tools

Slides are displayed during classes and are available on Virtuale.

Office hours

See the website of Andrea Bedini

See the website of Monica Baiula