78942 - Biochemistry

Course contents

MODULO for Orthopedic techniques and Dietistic

Flavio FLAMIGNI

• The chemical foundations of biochemistry. Water and pH.
• Amino acids, peptides and proteins.  
• Enzymes and their regulation. Coenzymes and vitamines.
  
• Bioenergetics and role of ATP. Catabolism and anabolism.
• Structure and metabolism of carbohydrates. Digestion of carbohydrates. Blood glucose and its regulation. Overview of carbohydrate metabolism. Glycogen synthesis and glycogenolysis. Glycolysis and glucogenesis. Pentose phosphate cycle.
• Pyruvate oxidation and citric acid cycle (TCA cycle). Respiratory chain and oxidative phosphorylation.
• Structure of lipids. Overview of lipid metabolism. Digestion of lipids. Plasma Lipoproteins. Lipolysis and lipogenesis. beta-oxidation of fatty acids. Ketone bodies. Cholesterol.
• Metabolism of nitrogen compouds. Digestion of proteins. Overview of amino acid metabolism. Fate of carbon skeleton and amino group of aminoacids. Urea cycle. Gluconeogenesis. Biogenic amines.
  
• Signal transduction Nuclear and membrane receptors. Main hormones regulating metabolism: glucagon, insulin, catecholamines, glucocorticoids.
• Metabolic interelations among tissues. Biochemistry of bone and cartilage. Collagen, glycosaminoglycans. Regulation of blood calcium.

 

MODULO 2 (only for Dietistic)

Silvia CETRULLO

• Nucleosides, nucleotides, and nucleic acids.
• Lactose intolerance; galactosemia; fructosemia; ethanol metabolism.
• Xylulosuria and thiamine deficiency; favism; pyruvate dehydrogenase deficiency.
• Cyanide poisoning; hyperlactatemia in athletes; impaired perfusion metabolic acidosis; anabolic effects of insulin.
• Hyperchylomicronemia; familial hypercholesterolemia; medium-chain fatty acid acyl-coA dehydrogenase deficiency.
• Phenylketonuria; urea cycle defects; maple syrup urine disease; ADA-SCID.

Office hours

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