97322 - PATOLOGIA GENERALE -

Learning outcomes

At the end of the course the student is able to understand the mechanisms underlying the main disorders

Course contents

CELLULAR PATHOLOGY
-Etiology and pathogenesis
-Cellular adaptations: hyperplasia, atrophy, metaplasia
-Cell damage, autophagy, apoptosis and necrosis
DEFENSE MECHANISMS and IMMUNOLOGY
-Damage signals and the damage response
-Innate immune system
-Acute and chronic inflammation
-Systemic effects of inflammation, fever and thermoregulation
-Repair of wounds
-Hemostasis and coagulation cascade
-Adaptive immunity: B and T cells
- Vaccines
INFECTIOUS DISEASES
- Infectious Agents - Viruses
-Mechanisms of Infection - SARS-Cov-2
-Epidemiology and Diagnosis of Infections - SARS-Cov-2
-Prevention and Treatment of Infections - SARS-Cov-2
MOLECULAR BIOLOGY AND GENETIC PATHOLOGY
-Maintenance and transmission of genetic information
-DNA and RNA
-DNA mutations
-Genetic diseases
autosomal dominant inheritance
autosomal recessive inheritance
X-linked
- Chromosomal disorders
ONCOLOGY
-Characteristics of the tumor cell
-Neoplastic process
-Classification of tumors
-Molecular genetics of tumors, oncogenes and tumor suppressors
-Carcinogenic Agents
-HPV - Mechanisms of carcinogenesis
-HPV - Epidemiology and prevention
ABUSE DISORDERS
-Ethanol metabolism
-Damage from alcohol
-Pathogenesis of Alcoholic Steatosis
-Systemic Effects of Alcohol
METABOLIC DISEASES
-Obesity
-Dyslipidemias
-Lipid metabolism
-Diabetes
Classification
Pathogenesis and Epidemiology
Complications
Genetics of Diabetes
-Interaction of Obesity and Diabetes

Readings/Bibliography

At the beginning of the integrated course (I.C.), students will receive indication on updated didactic materials produced in electronic format by other professors teaching General pathology (MED/04) in different graduate courses. These materials are stored on AMS Campus AlmaDL University of Bologna website: http://campus.unibo.it/ . Username and password are those given to each student of the University of Bologna.

Moreover, ad hoc software programs will be made available

Teaching methods

Ex-cathedra lessons and practices on computers

Further readings:

1. J.A.M. Maier – “Patologia generale e fisiopatologia per le professioni sanitarie” II edizione – Mc Graw Hill Editore (recommended)
2. E. Rubin, H.M. Reisner – “Patologia generale – l’essenziale” - Piccin Editore (reference book)
3. G.M. Pontieri - “Patologia generale e fisiopatologia generale. Per i corsi di laurea in professioni sanitarie” III edizione - Piccin Editore (reference book)
4. T.K. Mak, M. Saunders - "Fondamenti di immunologia" - Zanichelli editore (reference book)

Teaching methods

Lectures (24 hours).

Assessment methods

Student learning will be checked at the end of the course through a written, true/false quiz.

Teaching tools

Teaching slides will be available on line at Unibo e-learning website https://iol.unibo.it

Office hours

See the website of Paolo Garagnani