00768 - General Pathology

Learning outcomes

At the end of the course, students will be able to understand the causes and pathogenic mechanisms of human diseases. Occupational and environmental causes of disease will be examined as well as their pathological consequences. The students will learn the principles and biological basis of immune response regulation, including the pathophysiology of immune diseases.

Course contents

CELLULAR PATHOLOGY
-Etiology and pathogenesis
-Cellular adaptations: hyperplasia, atrophy, metaplasia
-Cell damage, autophagy, apoptosis and necrosis
DEFENSE MECHANISMS and IMMUNOLOGY
-Damage signals and the damage response
-Innate immune system
-Acute and chronic inflammation
-Systemic effects of inflammation, fever and thermoregulation
-Repair of wounds
-Hemostasis and coagulation cascade
-Adaptive immunity: B and T cells
- Vaccines
INFECTIOUS DISEASES
- Infectious Agents - Viruses
-Mechanisms of Infection - SARS-Cov-2
-Epidemiology and Diagnosis of Infections - SARS-Cov-2
-Prevention and Treatment of Infections - SARS-Cov-2
MOLECULAR BIOLOGY AND GENETIC PATHOLOGY
-Maintenance and transmission of genetic information
-DNA and RNA
-DNA mutations
-Genetic diseases
autosomal dominant inheritance
autosomal recessive inheritance
X-linked
- Chromosomal disorders
ONCOLOGY
-Characteristics of the tumor cell
-Neoplastic process
-Classification of tumors
-Molecular genetics of tumors, oncogenes and tumor suppressors
-Carcinogenic Agents
-HPV - Mechanisms of carcinogenesis
-HPV - Epidemiology and prevention
ABUSE DISORDERS
-Ethanol metabolism
-Damage from alcohol
-Pathogenesis of Alcoholic Steatosis
-Systemic Effects of Alcohol
METABOLIC DISEASES
-Obesity
-Dyslipidemias
-Lipid metabolism
-Diabetes
Classification
Pathogenesis and Epidemiology
Complications
Genetics of Diabetes
-Interaction of Obesity and Diabetes

Readings/Bibliography

At the beginning of the integrated course (I.C.), students will receive indication on updated didactic materials produced in electronic format by other professors teaching General pathology (MED/04) in different graduate courses. These materials are stored on AMS Campus AlmaDL University of Bologna website: http://campus.unibo.it/ . Username and password are those given to each student of the University of Bologna.

Moreover, ad hoc software programs will be made available

Teaching methods

Ex-cathedra lessons and practices on computers

Further readings: 

1. J.A.M. Maier – “Patologia generale e fisiopatologia per le professioni sanitarie” II edizione – Mc Graw Hill Editore (recommended)
2. E. Rubin, H.M. Reisner – “Patologia generale – l’essenziale” - Piccin Editore (reference book)
3. G.M. Pontieri - “Patologia generale e fisiopatologia generale. Per i corsi di laurea in professioni sanitarie” III edizione - Piccin Editore (reference book)
4. T.K. Mak, M. Saunders - "Fondamenti di immunologia" - Zanichelli editore (reference book)

Teaching methods

Lectures (24 hours).

Assessment methods

Student learning will be checked at the end of the course through a written, true/false quiz.

Teaching tools

Teaching slides will be available on line at Unibo e-learning website https://iol.unibo.it 

Links to further information

http://corsi.unibo.it/educazioneprofessionale/Pagine/default.aspx

Office hours

See the website of Paolo Garagnani