- Docente: Luca Morandi
- Credits: 2
- SSD: BIO/12
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in School of Dentistry (cod. 8204)
Learning outcomes
Describe the clinical biochemistry skills and techniques to evaluate the functional state of organs and tissues, using liquid and solid samples from patients.
Course contents
Course contents:
- Course introduction
- Laboratory medicine: the pre-analytical, analytical and post-analytical phases
- Variability and standardization of laboratory testing
- Performance of a laboratory test: sensitivity, specificity, predicting values, ROC curves, clinical validation.
- Personalized medicine: new diagnostic and bioinformatic approaches that provide understanding of the molecular basis of disease and stratify related patients
- Principle of epigenetics
- The use of genetic and epigenetic biomarkers in oncology and neurological disorders
- The assessment of diagnostic, prognostic and predictive tests with examples from new assays based on Next Generation and nanopore Sequencing
- Liquid biopsy to monitor the evolution of the cancer genome through a minimally invasive technique
- Tumor heterogeneity and single cell sequencing
- Bioinformatic tools in Clinical molecular biology and radiogenomics
- Oral cancer genetic and epigenetic modifications
- The development of a new diagnostic and prognostic assay to early detect oral cancer using bisulfite NGS
- Cerebrospinal fluid analysis in the central nervous system diseases
Readings/Bibliography
Files will be provided by IOL platform (.pdf slides, video, reference papers)
Teaching methods
Lectures
Assessment methods
Oral examination
Teaching tools
Power point presentations, video, assessment tests using .quizizz platform
Office hours
See the website of Luca Morandi