00031 - Pathological Anatomy (A-KH)

Learning outcomes

The course aims to provide students knowledges about the main epidemiological, etiological, morphological, phenotypic and clinical-pathological features of the most important neoplastic and non-neoplastic diseases (inflammatory, degenerative and ischemic) of the following apparata: cardiovascular, hematologic, respiratory, gastro-intestinal, urinary, male and female reproductive system, as well as breast, and endocrine system,  liver and biliary tract, pancreas, central nervous system, skin, bone and soft tissue. At the end of the course, the student will must be able to: - correctly decode the histo-pathological diagnosis of these diseases, with a clear perception of their prognostic and therapeutic value.

Course contents

Program carried out by Prof. A. D'Errico.

Diseases of the liver and biliary tract

Cirrhosis. Pathogenesis and morphological features.

Viral hepatitis. Etiologic agents, pathogenesis and pathological features. Fulminant hepatitis, acute hepatitis, chronic hepatitis.

Non-viral liver disease. Alcoholic liver disease, autoimmune hepatitis, liver disease from drugs and toxins, hemochromatosis, Wilson Disease, alfa-1 anti-trypsin deficiency, neonatal hepatitis. Liver abscess.

Diseases of the intrahepatic bile ducts. Pathologic features and pathogenesis.  Primary biliary cirrhosis and primary sclerosing cholangitis.

Tumors and tumor-like lesions. 

Benign tumours: Angioma,  Focal nodular hyperplasia, Hepatocellular adenoma.

Malignant tumours: Hepatocellular carcinoma, cholangiocarcinoma.

Metastatic tumors.

Extrahepatic bile ducts. 

Inflammatory pathology of extrahepatic biliary tract: classification. 

Pathologic features andpathogenesis of adenocarcinoma of the extrahepatic bile ducts and Ampullary adenocarcinoma.

Gallbladder. Acute and chronic cholecystitis. Gallbladder adenoarcinoma.

Female genital system

Pre-neoplastic and neoplastic disease of the vulva, vagina and cervix. Pathological features and pathogenesis of: human papillomavirus infection and correlations with vulvar (VIN), vaginal (VAIN) and cervical (CIN and SIL) Intraepithelial Neoplasia . 

Squamous cell carcinoma of the female genital tract (vulva, vagina, cervix): pathological features, natural history, diagnosis and pathological staging.

Endometritis. Adenomyosis and endometriosis

Endometrial hyperplasia and its correlation with endometrial carcinoma. The endometrial polyps. Classification, pathologic features, grading and staging of endometrial carcinoma. 

Leiomyoma and leiomyosarcoma.

 Cysts and tumors of the ovary. Pathology and pathogenesis. The polycystic ovary. Classification and pathogenesis  of ovarian cancers (serous, mucinous, endometrioid, Brenner tumor, gonadal stromal tumors and germ cell tumors).

Pathology of pregnancy. Pathology and pathogenesis. Complete, partial and invasive mole. Choriocarcinoma

Readings/Bibliography

Pathologic Basis of Disease. ROBBINS AND COTRAN. VII EDITION THE LECTURES ARE ESSENTIAL FOR THE COMPREHENSION  AND KNOWLEDGE OF THE PATHOLOGICAL ANATOMY.

Teaching methods

Lectures. Discussion with the students. Access to diagnostic activity.

Assessment methods

Test at the end of the course.

Teaching tools

The student can integrate the teaching course, attending the routine activities at the Service of Pathological Anatomy Pad 26, in agreement with the teacher. The routine activity implies sampling of the surgical specimens, the revision of the slides at the multiple microscope, and the autoptic activity.

Office hours

See the website of Antonietta D'Errico