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83169 - CLINICAL BIOCHEMISTRY

Anno Accademico 2022/2023

                
                        Docente:
                        Luca Morandi
                    
                        Crediti formativi:
                        1
                    
                        SSD:
                        BIO/12
                    
                        Lingua di insegnamento:
                        Inglese
                    
                        Modalità didattica:
                        Convenzionale - Lezioni in presenza
                        
                            Campus:
                            Bologna
                        
                            Corso:
                            Laurea Magistrale a Ciclo Unico in
                            Medicine and Surgery (cod. 9210)

                            Risorse didattiche su Virtuale
                        
                                    Orario delle lezioni
                                
dal 10/10/2022 al 05/12/2022

Conoscenze e abilità da conseguire

Describe the clinical biochemistry skills and techniques to evaluate the functional state of organs and tissues, using liquid and solid samples from patients.

Contenuti

Course contents:
Course introduction
Laboratory medicine: the pre-analytical, analytical and post-analytical phases
Variability and standardization of laboratory testing
Performance of a laboratory test: sensitivity, specificity, predicting values, ROC curves, clinical validation.
In Vitro Diagnostic Medical Device Regulation (IVDR)
Personalized medicine: new diagnostic and bioinformatic approaches that provide understanding of the molecular basis of disease and stratify related patients
The assessment of diagnostic, prognostic and predictive tests with examples from new assays based on Next Generation and nanopore Sequencing
Principle of epigenetics
The use of genetic and epigenetic biomarkers in oncology and neurological disorders
Tumor heterogeneity and single cell sequencing
Liquid biopsy to monitor the evolution of the cancer genome through a minimally invasive technique
Bioinformatic tools in Clinical molecular biology and radiogenomics

Testi/Bibliografia

Lecture slides and scientific literature will be provided (see IOL platform)

Metodi didattici

Frontal teaching

Modalità di verifica e valutazione dell'apprendimento

Final evaluation will be performed by means of a joint test on all topics covered in the integrated course. The test will be based on 40 multiple choice questions (4 available answers, only one is correct). In general, at least 5 questions from each different teaching module will be included in the test. The exam is passed (score 18) when at least 24 questions are correctly answered. When all the questions are answered correctly the final score will be 30, with honours.

Strumenti a supporto della didattica

Lecture slides will be made available.

www.quizizz.com platform to verify learning activities at the end of each lecture

Orario di ricevimento

Consulta il sito web di Luca Morandi