81281 - Neurobiology and Animal Models of Neurological Diseases

Learning outcomes

At the end of the course the student will know the basic principles of anatomy and function of the nervous system, with particular reference to the molecular mechanisms of synaptic transmission and neuronal trophism; will know the main mechanisms of reaction to noxious detrimental to the different cell populations of the Nervous System; will be able to read critically the literature relating to the models in vitro and in vivo of diseases of the nervous system, including the demanza's disease.

Course contents

MODULUS 1

Neurobiology:

The cytoskeleton of the neuron and axonal transport

Electrical activity of the neuron

Neurotransmitters, neuropeptides, trophic factors

Metabotropic and ionotropic receptors

Neuron response to injury

Apoptosis, autophagy and necrosis within the CNS

Inflammation in the central nervous system

Neural stem cells in the adult brain

Chemical neuroanatomy:

The cholinergic systems

The aminergic systems

The amino acid systems

The peptidergic systems

MODULUS 2

Vitro and in vivo models for Alzheimer's disease

Vitro and in vivo models for the multiple sclerosis

Vitro and in vivo models for vascular and traumatic brain and spinal cord injury

Models of neurological disease on a genetic basis

Readings/Bibliography

Kandel E., Principi di Neuroscienze, Casa Editrice Ambrosiana
Hall Z.W., Molecular Neurobiology
Siegel GJ et al., Basic Neurochemistry, Lippincott Raven

International literature

Teaching methods

lectures

Assessment methods

exam at the end

Teaching tools

power point slides

Office hours

See the website of Luciana Giardino

See the website of Luca Lorenzini