81281 - Neurobiology and Animal Models of Neurological Diseases

Learning outcomes

At the end of the course the student will know the basic principles of anatomy and function of the nervous system, with particular reference to the molecular mechanisms of synaptic transmission and neuronal trophism; will know the main mechanisms of reaction to noxious detrimental to the different cell populations of the Nervous System; will be able to read critically the literature relating to the models in vitro and in vivo of diseases of the nervous system, including the demanza's disease.

Course contents

Neurobiology:

The cytoskeleton of the neuron and axonal transport, 3 hours

Electrical activity of the neuron, 3 hours

Neurotransmitters, neuropeptides, trophic factors, 3 hours

Metabotropic and ionotropic receptors, 3 hours

Neuron response to injury, 3 hours

Apoptosis, autophagy and necrosis within the CNS, 3 hours

Inflammation in the central nervous system, 3 hours

Neural stem cells in the adult brain, 3 hours

 

Chemical neuroanatomy:

The cholinergic systems, 3 hours

The aminergic systems, 3 hours

The amino acid systems, 3 hours

The peptidergic systems, 3 hours

 

Models of illness:

Vitro and in vivo models for Alzheimer's disease, 3 hours

Vitro and in vivo models for the mutiple sclerosis, 3 hours

Vitro and in vivo models for vascular and traumatic brain and spinal cord injury, 3 hours

Models of neurological disease on a genetic basis, 3 hours

Readings/Bibliography

Teaching methods

lectures

Assessment methods

exam at the end

Teaching tools

power point slides

Office hours

See the website of Luciana Giardino