- Docente: Flavia Frabetti
- Credits: 9
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 8415)
Learning outcomes
At the end of the course the student should know: the organization and the main molecular mechanisms of eukariotic cells; the organization of genetic information, its transmission and expression; the reproduction of cells and organisms.
Course contents
Modern Biology introduction
The cellular and molecular biology.
Properties of living organisms; relationship between organisms and
their ambient.
The Biology Science evolution from cellular theory and microscopy
to System Biology.
Genome, transcriptome, proteome, metabolome: new topics in medical
science.
Genomics and post-genomics methods of the translational
Medicine.
The eukariotic cells and their properties
The cell theory. Shape, size and structure of eukaryotic cells.
Theories on the origin of life. Genes and genomes evolution. The
origin of cellular organels and pluricellularity. Criteria of
classification of the organisms.
The genome information structure and the gene expression
controls
The nucleus: DNA, chromatin, chromosomes. The ipothesis of
chromosomal territories. New informative codes: histone code and
nucleosome code. Epigenetic: a new frontier in the cellular
information knowledge. Mechanisms of gene expression regulation.
Levels of control: transcriptional, post-transcriptional,
translational and post-translational events. The non coding genes:
ncRNAs. Function in silencing of human genes.
Differentiation and gene expression during the early organisms development.
Cells interactions and comunication. Cell-cell interactions (induction and lateral inhibition) and cytosolic determinants.
Cell division and cell death
The cell cycle: phases and mechanisms of control.
Cycline dependent kinase and their function.
The brakes of cell cycle: p53.
The induction of cell division: growth factors. EGF signalling.
Apoptosis: role in the organisms's omeostasis.
Different pathways and functions between necrosis and apoptosis.
Cancer biology
Aberrations on cellular functions and pathology.
Cancer genetics. Oncogenes, oncosoppressors and caretaker genes.
New molecular targets in therapy: the translational medicine.
Reproduction
The two main strategies: sexual and asexual reproduction.
Gamets and their production. Human fertilization phases and molecules.
Readings/Bibliography
Teaching methods
Assessment methods
Teaching tools
Links to further information
http://apollo11.isto.unibo.it/
Office hours
See the website of Flavia Frabetti