37201 - Metabolic Biochemistry (A)

Learning outcomes

At the end   of the course the   student knows :   the essential elements   of the   intermediary metabolism   of the major   biological molecules   ( carbohydrates, lipids   and nitrogen compounds ), the   energy   changes   associated with them , their   interrelationships in response to metabolic and   hormonal   regulation ,   as well as   the cellular and tissue localization   of the   cell   major   metabolic pathways ;   the specialization   of the various   organs   and tissues   in   metabolic activities.  

Course contents

It is an integrated course and consist of various topics which are  described in the global programme of the integrated course.
The programme of Prof. Guarnieri consists of the following arguments:
General concepts on energetic and metabolic regulation.
Carbohydrate metabolism :
Digestion of carbohydrates;Glycogen metabolism;Glycolysis;Pentose phosphate cycle;Gluconeogenesis;Hormonal and metabolic regulation of the glucidic
metabolism.Pyruvate oxidation and tricarboxylic Kreb's cycle;Mitochondrial ATP production.
Lipid metabolism : General aspects of triacygligerol and complex lipids. Digestion of lipids ;Lipolysis and lipogenesis;ketogenesis;Complex lipid biosynthesis and catabolism. Cholesterol metabolism and functions;Plasmatic lipoproteins. Bile acids and steroid hormones.
Protein metabolism :
Digestion of proteins;Biosynthesis and degradation of aminoacids;Urea cycle;Neurotransmitters;Biosynthesis and degradation of purine and
pyrimidine nucleotides.Biogenic amines.
Metabolic regulation in different physiological and pathological conditions
(feeding,starvation,exercise,diabete,obesity)
Main biochemical pathways in human organs and tissues (liver, muscle, adipose, nervous and bone tissues, kidney)

Readings/Bibliography

M.Lieberman,A.D.Marks
Biochimica Medica: un approccio clinico
Seconda Edizione - Casa Editrice Ambrosiana

G.Tettamanti

Biochimica Medica:strutturale,metabolica e funzionale

Quarta  Edizione – Casa Editrice Piccin

 

J.W.Baynes,M.H. Dominiczack

Biochimica per le discipline biomediche

Terza edizione -  Casa Editrice Elsevier

Teaching methods

Lessons also integrated with seminars and biochemical discussions of clinical cases.

Assessment methods

Oral examination

Teaching tools

Notes and diagrams are available on CD's and on the web site ALMA@DL - AMS Campus

Office hours

See the website of Carlo Guarnieri