- Docente: Barbara Luppi
- Credits: 8
- SSD: CHIM/09
- Language: Italian
- Moduli: Barbara Luppi (Modulo 1) Barbara Luppi (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Chemistry and Pharmaceutical Technologies (cod. 8412)
Course contents
MODIFIED DRUG RELEASE - 4 cfu (Prof. B. Luppi)
Bioavailability and Modified drug release
Immediate release systems and modified release systems: definition, biopharmaceutical, clinical and indutrial aim. The concept of biopharmaceutics. LADME. Bioequivalence. Important factors influencing steady-state plasma concentration of a drug. Repeat action versus sustained action drug therapy.
Diffusion in polymeric systems
Polymeric systems and main mechanism of drug release. Theory of mass transfert. Fick's First and Second Lows. Diffusion coefficient. Partition coefficient. Stagnant diffusion layer. Macroporous systems, microporous systems and unporous systems. Diffusion through hydrate polymers. Solubility and partition coefficient.
Modified drug delivery systems
Controlled release kinetics. A) Diffusion controlled devices. I) Monolithic devices. II) Reservoir devices. B) Chemically controlled devices. C) Solvent controlled devices: I) Osmotically controlled devices. II) Swelling controlled devices. D) Pulsatile systems and intelligent systems.
DRUG DELIVERY - 4 cfu (Prof. B. Luppi)
Enhancement of solubility and dissolution rate
Dissolution and Noyes-Whitney Law. Thermodynamic parameters (Gibbs equation and Van't Hoff equation). Solubility enhancement strategies. Micellation. Complexation. Cyclodextrins and phase-solubility diagrams. Salification.
Pharmaceutical polymers
Classification. Crystalline and amorphous polymers. Polymer synthesis: addition polymerization and condensation polymerization. Water-soluble polymers. Water-insoluble polymers. Biocompatible and biodegradable polymers. Examples of pharmaceutical polymers.
Drug targeting and site-specific delivery
Main mechanisms of spatial controlled drug release: drug targeting and site-specific delivery. Passive targeting. Physical targeting. Active targeting. Pharmaceutical carries. Micro and nanoparticulate carriers (spheres, capsules, liposomes, niosomes, polymeric micelles, solid lipid nanoparticles), macromolecular carriers and cellular carriers.
Readings/Bibliography
A.T. Florence, D. Attwood, Physicochemical Principles of Pharmacy, Pharmaceutical Press, 2011
P. Colombo et al., Principi e Tecnologie Farmaceutiche, casa Editrice Ambrosiana, Milano, II Ed. 2015
Slides discussed during the course
Teaching methods
Theoretical lectures. Multiple choise test for discussion during class.
Assessment methods
Oral examination. For the oral examination, registration by AlmaEsami list is required.
Teaching tools
Video-projector and PC.
Office hours
See the website of Barbara Luppi
SDGs
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.