Scheda insegnamento

  • Docente Pier Luigi Martelli

  • Crediti formativi 6

  • SSD BIO/10

  • Modalità didattica Convenzionale - Lezioni in presenza

  • Lingua di insegnamento Inglese


L'insegnamento contribuisce al perseguimento degli Obiettivi di Sviluppo Sostenibile dell'Agenda 2030 dell'ONU.

Salute e benessere La vita sulla terra

Anno Accademico 2018/2019

Conoscenze e abilità da conseguire

At the end of the course, the student acquires advanced machine learning based approaches (Support Vector Machine, Conditional Random Fields, Hybrid methods) to complement previous expertise. Problems of Systems Biology will be introduced with focusing on network theory and dynamic modeling to approach complexity at the cell level. In particular, the student will be able to: - understand and modeling biological complexity; - modeling time evolution of a biological system; - predicting protein-protein interaction and DNA/RNA protein interaction.


Neural Networks
Support Vector Machines
Kernel methods
Deep learning methods
Decision trees and Random Forests

Applications to protein structure and function prediction

Biological Systems
Experimental Techniques
Genomics, Proteomics, Interactomics, Transcriptomics, Metabolomics, Metagenomics, Epigenomics

Basics on Model
Mathematical Methods: Networks
Mathematical Methods: Differential equations

Kinetics of biochemical reactions and simple metabolic pathways

Transcription networks in Prokariotes.
Analysis of simple motifs (self-regulation, Feed-forward loops)


Slides of the lecture and papers cited therein
Suggested books for a deeper study: 
Bishop C (2006) Pattern recognition and Machine Learning. Springer [ISBN 0-38-731073-8]

Ingalls BP (2013) Mathematical Modeling in Systems Biology.  MIT press [ISBN: 9780262018883]
Aron U. (2006) An Introduction to Systems Biology: Design Principles of Biological Circuits. Chapman & Hall/CRC Mathematical and  Computational Biology (Vol. 10) [ISBN-13: 9781584886426]

Metodi didattici

Lezioni frontali

Modalità di verifica dell'apprendimento

The final exam consists of a written test followed, if necessary, by an oral discussion.
It aims at assessing the achievement of the learning goals of the course:
- the knowledge of the theory and applications of machine learnint tools for Bioinformatics

- the knowledge of the theory of complex networks and their application to the description of biological systems;

- the analysis and integration of omics data

- the knowledge of the basic theory of ordinary differential equations and their application to the description of biological systems.

Strumenti a supporto della didattica

Orario di ricevimento

Consulta il sito web di Pier Luigi Martelli