- Docente: Stefano Iotti
- Credits: 3
- SSD: BIO/12
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Pharmaceutical Biotechnology (cod. 8519)
Learning outcomes
At the end of the course, the student will have the basic knowledge:
- about some advanced non-invasive diagnostic techniques and the physical principles on which they are based;
- about the metabolic and biochemical information obtainable from the different types of non-invasive investigation.
In particular, the student will be able to use metabolic information to understand the mechanisms of in vivo regulation and to understand the procedures of investigation and analysis of the data obtained by in vivo metabolic study.
Course contents
Physical principles of nuclear magnetic resonace spectroscopy (NMR). NMR application in in-vivo biochemistry. Integration between holistic and reductionist approaches. In vivo 31P spectroscopy in human brain and skeletal muscle (31P MRS). In vivo 1H spectroscopy in human brain (1H MRS).
In vivo phosphorus nuclear magnetic resonance spectroscopy (31P MRS). Basic principles of bioenergetics metabolism. The study of bioenergetics in vivo in the human brain and skeletal muscle. Examples of diagnostic applications
Spettroscopia in vivo di risonanza magnetica del protone 1H MRS).
Meatabolic relevance of the signals detectable in vivo in the human brain. Examples of diagnostic applications
Readings/Bibliography
specific scientific papers and handouts will be given by the teacher.
Teaching methods
frontal lessons with several group discussion of specific issues
Assessment methods
WRITTEN TEST WITH 31 MULTIPLE-CHOICE QUESTIONS
Teaching tools
Teaching materials: the didactic material presented in class will be made available to the student in electronic format
Office hours
See the website of Stefano Iotti