- Docente: Stefano Boschi
- Credits: 4
- SSD: CHIM/03
- Language: English
- Teaching Mode: Traditional lectures
- Campus: Rimini
- Corso: Single cycle degree programme (LMCU) in Pharmacy (cod. 5987)
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from Oct 19, 2023 to Dec 15, 2023
Learning outcomes
The students should acquire basic knowledge of radiochemistry, they should have a global overview of the production and quality control process of radiopharmaceuticals for research and clinical use. The students should also learn the basic requirements concerning purity, safety and efficacy of radiopharmaceuticals as well as the role of quality assurance systems for the production of radiopharmaceuticals.
Course contents
Imaging techniques and molecular imaging SPECT and PET.
The radiopharmaceutical, definition, purpose, structures. Concept of metabolic and receptorial radiopharmaceuticals. General features of radiopharmaceuticals for diagnostics and therapy in nuclear medicine.
Radionuclides: classification of radionuclides according to the type of emission and their use in nuclear medicine
Introduction to the kinetics of radiopharmaceutical.
Radioactivity and radioactive decay: α, β +, β-, γ, EC decay, isomeric transitions. Law of radioactive decay and unit of measurement of radioactivity.
Main production processes of radionuclides.
The γ-emitting radiopharmaceuticals: the 99Mo / 99mTc generator, technetium-99m chemistry, labelling strategies and radiopharmaceuticals used in diagnostic nuclear medicine.
Positron-emitting radiopharmaceuticals: cyclotron production, F-18 chemistry, electrophilic and nucleophilic substitution reactions with F-18, synthesis of 18F-FDG. Production and chemistry of C-11, synthesis of C-11 radiopharmaceuticals.
Automation processes and site planning in radiopharmacy.
Radiopharmaceuticals labeled with Ga-68: Ge-68/Ga-68 generator, gallium chemistry, synthesis strategies, clinical and experimental uses.
Theranostics and radiopharmaceuticals for radiometabolic therapy
Quality control of radiopharmaceuticals: parameters and analytical methods. Validation of analytical methods.
Mechanism of action of metabolic and receptorial radiopharmaceuticals.
Regulatory aspects of radiopharmaceuticals. Classification, galenic, magistral, experimental radiopharmaceuticals. The European Pharmacopoeia. Organization and monographs.
Quality assurance. Introduction to GMPs and description of the Good Preparation Standards for Radiopharmaceuticals for Nuclear Medicine (NBP-MN)
Readings/Bibliography
Slides, chapters and scientific papers will be provided
Teaching methods
Lectures (frontal teaching) and online teaching
Assessment methods
Oral examination in attendance or online. It can be converted into a written (multiple choices) exam if the needed
Office hours
See the website of Stefano Boschi