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86869 - Diagnostic Molecular Pathology

Academic Year 2019/2020

                
                        Docente:
                        Michelangelo Fiorentino
                    
                        Credits:
                        6
                    
                        SSD:
                        MED/05
                    
                        Language:
                        Italian
                    
                        Teaching Mode:
                        Traditional lectures
                        
                            Campus:
                            Bologna
                        
                            Corso:
                            First cycle degree programme (L) in
                            Biotechnology (cod. 8005)

                            Teaching resources on Virtuale

Learning outcomes

The course aim to provide the sudent with the bases of diagnostic molecular pathology, with particular focus on solid tumors. At the end of the course the student will be confident of the basic knowledge for the running and the interpretation of molecular pathology diagnostic tests.

Course contents

The course aims to provide the students with the basic elements of diagnostic molecular pathology, with particular focus on solid tumors.

At the end of the course the student will learn the molecular bases of the main human solid tumors and the theory and the interpretation of the main techniques of diagnostic molecular pathology.

Program/Contents

Basic histopathology.
Techniques in histopathology.
Fundamentals of molecular diagnostics: in vitro techniques.
Fundamentals of molecular diagnostics: in situ techniques.
Immunohistochemistry.
Fluorescent and chromogenic in situ hibridization.
PCR/Real time PCR
Direct sequencing
NGS sequencing
Molecular tests predictive of response in personalized oncological medicine.
Focus on solid tumors: prostate cancer.
Focus on solid tumors :colo-rectal cancer.
Focus on solid tumors: breast cancer.
Focus on solid tumors: lung cancer.
Focus on solid tumors: kidney cancer.
Focus on solid tumors: melanoma.
Focus on solid tumors: liver cancer.
Focus on solid tumors: bladder cancer.
Focus on solid tumors: penile and cervical cancer.
Focus on solid tumors: brain cancer.

Readings/Bibliography

No particular reading are suggested for this course.

Teaching methods

The course consists of 6 CFU (class presentations).

Assessment methods

The final exam consists of a written test with 30 multiple choice questions on the matter of the presentations.
For each question, the student receives a vote. The weighted result based on the median performance of the other students and the standard deviation is expressed in 30/30.

Teaching tools

The teaching material will be made available on the Insegnamento Online IOL platform in electronic format.

Office hours

See the website of Michelangelo Fiorentino