- Docente: Andrea Milelli
- Credits: 4
- SSD: CHIM/08
- Language: English
- Teaching Mode: Traditional lectures
- Campus: Rimini
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Corso:
Single cycle degree programme (LMCU) in
Pharmacy (cod. 5987)
Also valid for Single cycle degree programme (LMCU) in Pharmacy (cod. 9078)
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from Mar 06, 2024 to May 23, 2024
Learning outcomes
The course deals with the fundamental strategies of design and synthesis of drugs and with the molecular mechanism of drug action.
Course contents
- Drug research and development.
- Strategies for lead compound identification.
- Combinatorial libraries.
- Molecular modifications of the lead.
-The concept of isostery and bioisostery and their applications.
- Strategies for molecular modification.
- Conformationally restricted analogues.
- Chiral modification.
- Chiral drugs.
- Molecular hybrids, bivalent ligands, address-message approach.
- Computer-aided molecular modelling.
- Design based on ligand structure and interaction site.
- Literature search on the web.
Teaching methods
The course includes theoretical lessons and laboratory exercises
Assessment methods
Oral Examination
Teaching tools
Video projector - PC system. The slides presented in class are made available to students at the University of Bologna via the IOL platform
Office hours
See the website of Andrea Milelli
SDGs
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.