84440 - ONCOLOGICAL PHARMACOLOGY

Conoscenze e abilità da conseguire

Describe the mechanism of action, indications and limitations of oncologic and antiemetic drugs.

Contenuti

Lecture 1 (2 h). ANTICANCER DRUGS – Part A. Compare and contrast mechanisms of action, indications, contraindications, adverse drug reactions of chemotherapy (traditional chemotherapy; e.g., anthracyclines, taxanes)

Lecture 2 (2 h). ANTICANCER DRUGS – Part B. Compare and contrast mechanisms of action, indications, contraindications, adverse drug reactions of targeted therapy (monoclonal antibodies vs small-molecules), including immunotherapy (immune checkpoint inhibitors) and hormone therapy (tamoxifen).

Lecture 3 (2 h). ANTIEMETIC DRUGS. Describe the mechanisms of action, indications and limitations of antiemetic medications: anti-dopaminergic drugs (domperidone vs metoclopramide), 5-HT3 receptor antagonists (ondansetron), tachykinin NK1 receptor inhibitors (aprepitant). The role of corticosteroids. Combination regimens. Classify the emetogenic potential of anticancer drugs.

Lecture 4 (2 h). SAFE PRESCRIBING IN ONCOLOGY. Understand peculiarities of drug development approach for oncological drugs. Prediction and management of clinically-relevant interactions and adverse drug reactions. Breast cancer as a case study.

Testi/Bibliografia

Suggested texbooks:

1) Hitchings, Lonsdale, Burrage, Baker. The top 100 drugs. Clinical pharmacology and practical prescribing. 2nd Edition, 2019, Elsevier.

2) Goodman and Gilman’s Manual of Pharmacology and Therapeutics. 2nd Edition. 2014. The McGraw-Hill Companies.

Metodi didattici

See english version

Modalità di verifica e valutazione dell'apprendimento

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Strumenti a supporto della didattica

See english version

Orario di ricevimento

Consulta il sito web di Emanuel Raschi