01218 - Clinical Immunology (L-Z)

Course Unit Page

SDGs

This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.

Good health and well-being

Academic Year 2019/2020

Learning outcomes

  • Discuss the fundamental mechanisms underlying protective immune responses.
  • Describe the fundamental mechanisms underlying immunologic disease and associate these mechanisms with strategies for therapeutic modulation of the immune system.
  • Appreciate the basic immunological principles underlying biotherapeutics, recognize the commonality among diverse organ-specific disease states and infer the mechanisms of therapeutic effect.
  • Analyze the medical literature reporting immunologic advances pertinent to their patients, cite the rationale for use of new immunodiagnostic and immunotherapeutic modalities in their patients.

Course contents

Anatomy and cells of the immune system. Innate immunity I: physical and humoral protection. Innate immunology II: cellular mechanisms. Acquired immunity: antigen receptors. The human leukocyte antigens. Cellular immune responses I: dendritic cells, macrophages and B lymphocytes. Cellular immune responses II: T lymphocytes, antigen presentation and natural killer cells. The immune response to microbes: an overview. Tolerance and mechanisms of autoimmunity. Hypersensitivity reactions and clinical allergy. Transplantation. Endocrine autoimmune disease. Liver diseases. Gastrointestinal diseases. Immune-mediated nephritis and vasculitis. Immune-mediated skin disease. Immune-mediated diseases of the nervous system and eye. Immunodificiency. Immunological manifestations of haematological disease. Immune-based therapies. Immunisation.

Readings/Bibliography

Clinical immunology : principles and practice (Fifth Edition)

Autore: Robert R Rich

Editore: Oxford : Elsevier, 2018.

Teaching methods

Formal lessons

Assessment methods

Multiple Choice Quiz

Teaching tools

Additional references will be provided during the course

Office hours

See the website of Luigi Muratori