65822 - Epigenetics

Course Unit Page

Academic Year 2018/2019

Learning outcomes

Students will acquire notions about the basic molecular mechanisms responsible for epigenetic phenomena  with a special emphasis on X-chromosome inactivation, allelic exclusion and DNA methylation dynamics during embryogenesis

Course contents

Lectures will deal with the following subject matters: X-chromosome inactivation, Genomic imprinting, Allelic exclusion, paramutation in plants, RNA interference,  chromatin organization, DNA methylation dynamics during embryogenesis, HSP90 buffering.

Readings/Bibliography

Scientific papers from top ranked journals such as Cell, Science, and Nature.

Teaching methods

Standard lectures and paper-reading

Assessment methods

Oral exam focusing on the general expects of the epigenetics phenomena, with a special attention on two paper articles to be chosen among those discussed in class.

Teaching tools

Slides and papers from scientific journals

Office hours

See the website of Giovanni Perini