00111 - Chemistry of Natural Organic Substances

Academic Year 2018/2019

  • Moduli: Stefano Masiero (Modulo 1) Stefano Masiero (Modulo 2)
  • Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
  • Campus: Bologna
  • Corso: First cycle degree programme (L) in Applied Pharmaceutical Sciences (cod. 8518)

Learning outcomes

The course will give the student a good knowledge of the various classes of natural organic compounds and the main biosynthetic pathways leading to secondary metabolites

Course contents

  • Intermolecular forces
  • Organic stereochemistry: biological outcomes.
  • Lipids: terpenes, steroids, fatty acids, triglycerides, phospholipids, prostaglandins, lipophilic vitamins.
  • Aminoacids, peptides and proteins.
  • Carbohydrates: monosaccarides, disaccarides, polysaccarides.
  • Heterocyclic aromatic compounds.
  • Nucleobases, nucleosides, nucleotides, nucleic acids.
  • Radical species and radical reactions.
  • Primary and secondary metabolism: general notes.
  • Acetate metabolic pathway.
  • Mevalonate metabolic pathway.
  • Shikimic acid metabolic pathway.
  • Alkaloids

Readings/Bibliography

W.H. Brown, "Organic Chemistry", III ed (or subsequent), Cengage Learning, , 2005

P. M. Dewick, "Medicinal Natural Products", 2nd ed. John Wiley& Sons, 2002

Teaching methods

Lectures

Assessment methods

The final examination, aiming at ascertaining the student's acquired skills, consists of a 40 min. oral  interview  on 3 different topics. Candidates are allowed to choose the first topic.

Teaching tools

Presentations. Files of presentations will be available for download.

Office hours

See the website of Stefano Masiero