Abstract
The COSMO project focuses on developing a new class of molecular shuttles, which are a most common type of artificial molecular machines. Unlike traditional designs, where a ring-like molecule moves between specific sites along an axle on rotaxanes, the proposed shuttles will feature a mobile component fully enclosed within a tubular molecule. These artificial nanotubes will be chemically tailored to recognize and interact with the guest molecule via non-covalent forces, with external stimuli used to control its movement. The project will initially investigate nanotubes with two active compartments, but these could evolve into longer, directional molecular motors. The systems will be analyzed in solution using spectroscopic and electrochemical techniques to understand their thermodynamic and kinetic properties. The tubular confinement is expected to influence the motion of the guest in unique ways. Furthermore, the nanotubes will be embedded in lipid membranes, potentially enabling controlled molecular or ionic transport across biomimetic membranes. These experiments could pave the way to innovative applications in control of biological functions and drug delivery.
Dettagli del progetto
Responsabile scientifico: Alberto Credi
Strutture Unibo coinvolte:
Dipartimento di Chimica Industriale "Toso Montanari"
Coordinatore:
ALMA MATER STUDIORUM - Università di Bologna(Italy)
Contributo totale di progetto: Euro (EUR) 203.089,00
Contributo totale Unibo: Euro (EUR) 72.746,00
Durata del progetto in mesi: 24
Data di inizio
16/10/2023
Data di fine:
15/10/2025
