Abstract
Alzheimer's disease (AD), the most common form of dementia, is marked by amyloid plaque (Aβ) accumulation, tau hyperphosphorylation, neuroinflammation, and neuronal degeneration. Despite significant efforts, effective treatment remains lacking. Disrupted communication between neurons and glia plays a key role in AD onset, with microglia-mediated neuroinflammation exacerbating neuronal damage. Extracellular vesicles (EVs) are involved in spreading neuroinflammation and toxic protein aggregates. EVs from neural stem cells (NSC-EVs) show promise in modulating neuroinflammation and enhancing neurogenesis in AD models. This study aims to examine adult neurogenesis and EV characteristics in the 5XFAD model, focusing on miRNA profiles and their potential as therapeutic targets for AD, which may lead to innovative treatments.
Dettagli del progetto
Responsabile scientifico: Francesca Massenzio
Strutture Unibo coinvolte:
Dipartimento di Farmacia e Biotecnologie
Coordinatore:
Università degli studi di Modena e Reggio Emilia - UNIMORE(Italy)
Contributo totale Unibo: Euro (EUR) 93.894,00
Durata del progetto in mesi: 24
Data di inizio
18/10/2023
Data di fine:
28/02/2026
