- Docente: Giorgio Milazzo
- Crediti formativi: 3
- SSD: BIO/18
- Lingua di insegnamento: Inglese
- Modalità didattica: Convenzionale - Lezioni in presenza
- Campus: Rimini
- Corso: Laurea Magistrale a Ciclo Unico in Pharmacy (cod. 9078)
Conoscenze e abilità da conseguire
Al termine del corso, lo studente possiede una conoscenza profonda circa i principi fondamentali dell'ereditarietà. Ha familiarità con la natura, trasmissione, espressione variabilità e manipolazione del materiale ereditario ed è in grado di comprendere, interpretare e valutare criticamente in modo rigoroso i dati sperimentali genetici.
Contenuti
- Introduction to genetics
- Mendelian Genetics
- Gregor Mendel and basic principles of heredity; monohybrid crosses (dominance and segregation); dihybrid crosses (independent assortment)
- Predicting the outcome of genetic crosses; probability and Chi-Square test
- Cell division, mitosis and meiosis, chromosomal basis of inheritance
- Sexual reproduction, mitosis and meiosis.Chromosome theory of inheritance
- Sex determination and sex-linked inheritance
- Dosage compensation in mammals
- Human pedigree analysis
- Extensions and modifications of basic mendelian principles
- Allelic variation and gene function; why some alleles are dominant and other recessive; types of dominance, reduced penetrance, lethal alleles.
- Genetic heterogeneity, gene interactions and epistasis.
- Linkage, recombination, gene mapping in Eukaryotes
- Linked genes and crossing over; Constructing genetic maps with recombination frequencies
- Linkage analysis in human; DNA polymorphisms as genetic markers; the lod-score method
- Overview of genetics of bacterial and viral genetic systems
- Genetic variation, DNA repair and recombination
- Genetic variability; mutation and polymorphisms; types of genetic variants; molecular basis of mutations; point mutations and their consequences; mutagenesis
- DNA repair mechanisms; DNA recombination mechanisms
- Variation in chromosome number and structure; mechanisms of structural variation
Testi/Bibliografia
Leland Hartwell, Michael L. Goldberg, Janice Fischer and Leroy Hood
6th edition
McGrawHill Education
Other textbooks:
Introduction to Genetic Analysis, by Griffiths, Wessler, Carroll, and Doebley.
Principles of Genetics , by D. Peter Snustad, Michael J. Simmons
Genetics. Analysis & Principles, by Robert J.Brooker
Concepts of Genetics, by Klug, Cummings, Spencer
Metodi didattici
Lectures with powerpoint presentations; in class problem solving and exercise
Modalità di verifica e valutazione dell'apprendimento
Final written and oral exam. Written will include multiple choice questions, questions with open answers and problem solving
Strumenti a supporto della didattica
Course materials (ppt presentations, problems and solutions, suggested readings) will be made available to students
Orario di ricevimento
Consulta il sito web di Giorgio Milazzo