- Docente: Lucia Catani
- Credits: 3
- SSD: MED/15
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Medical Biotechnology (cod. 8859)
Learning outcomes
Molecular and cellular bases for "targeted therapy" and "cellular therapy" to treat hematological malignancies and degenerative diseases. Molecular defects underlying hematological cancers. General organization of hematopoiesis with specific reference to "stem cell" compartment.
Course contents
Master Degree in Medical Biotechnology
Course: Second year
Course: Hematology-Blood diseases
Head of the course
Dott.ssa Lucia Catani
Lessons place:
Aula Didattica del Polo Murri -Policlinico Sant' Orsola
Programme
Hemopoietic system and regulatory mechanisms
Principles of cellular therapy: hemopoietic cells purification and ex vivo manipulation
Principles of cellular therapy: Hemopoietic stem cells transplantation
Principles of cellular therapy: the therapeutic potential of adult stem cells in tissue regeneration
Acute Myeloid Leukemia: classification, general concepts and bio-molecular characterization
Adoptive immunotherapy for tolerance in solid organ transplantation
Lymphoproliferative diseases: classification, general concepts and bio-molecular characterization
Chronic Myeloproliferative Diseases: molecular characterization and "targeted therapy"
Bone marrow microenvironment and stem cells mobilization
Mesenchymal stromal cells therapy
Readings/Bibliography
"Corso di Malattie del Sangue" S. Tura, M. Baccarani-Editore Esculapio Bologna. In addition, specific recent bibliography and web sites are suggested directly to students at the end of each lesson.
Teaching methods
Slides presentation: power-point
The topics covered are implemented with experimental results deriving from ongoing research projects.
Assessment methods
Oral exam at the end of the course of lessons upon registration.
The oral exam includes 3 specific questions (the first chosen by the candidate and the others at the discretion of the teacher).
The final exam aims to evaluate the achievement of the educational objectives:
- To know the biomolecular bases of haematopoietic development under normal and leukaemic conditions
- To understand the development processes of an experimental research plan and the evaluation of the results.
The final grade of the Integrated Course of Molecular Bases of Organ Pathologies II is defined, by means of an oral test, on the average of the scores reported on topics related to the main objectives of the Course.
Teaching tools
Slides are directly available for students.
Office hours
See the website of Lucia Catani