- Docente: Fabrizia Grepioni
- Credits: 6
- SSD: CHIM/03
- Language: Italian
- Moduli: Fabrizia Grepioni (Modulo 1) Simona Fermani (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Chemistry (cod. 9072)
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from Feb 28, 2024 to Apr 10, 2024
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from Apr 05, 2024 to May 31, 2024
Learning outcomes
Broad knowledge of morphological and structural characteristics of: (1) inorganic/macromolecular materials and nanomaterials produced by biological systems; (2) synthetic biomimetic materials for relevant technological applications. Basic knowledge of modern methods for the study of protein crystals via X-ray diffraction.
Course contents
Prerequisites: The student who accesses this teaching must be in possession of a good preparation in the fundamentals of inorganic chemistry and of the solid state.
Program of the I teaching unit:
1) Crystallography
3) X-ray diffraction: single crystal and powders
3) Polymorphism in crystalline solids
4) Solid state reactivity: mechanochemistry
5) Nanocrystalline solids: pigments
6) Biomaterials and bioceramics
Program of the II teaching unit
All the experimental steps and the problems for the resolution of the three-dimensional structure of a biological macromolecule will be treated in detail. Furthermore, the following crystallization methods will be illustrated theoretically and in the laboratory: vapor diffusion with drop drop and with drop, dialysis and batch drop.
Readings/Bibliography
Lecture notes, slides.
Reference texts:
Mann S. Biomimetic materials chemistry.Weinheim: Wiley-VCH; 1997
- Kendall JB, editor. Biomaterials Research Advances. New York, NY:Nova Science
Publishers; 2010:93–143.
- Dee KC, Puleo DA, Bizios R. An Introduction to Tissue-Biomaterial Interactions. Hoboken: Wiley-Liss; 2003.
- J.D. Guthrie and B.T. Mossman Health Effects of Mineral Dusts, edited by J.D. Guthrie and B.T. Mossman (Rev. Miner. 28, Chelsea, MI, 1993),
- Bergfors, T., Editor. Protein Crystallization: Second Edition. 2009. International
University Line, La Jolla, California.
- McPherson, A. Preparation and analysis of protein crystals, Krieger.
- Ducan E. Mc Ree, Practical Protein Crystallography, Second Edition.
Teaching methods
Lectures and lab units.
Assessment methods
Oral examinations (30-45 minutes)
Teaching tools
Overhead projector, PC, powerpoint, samples of biogenic and biomimetic materials.
Office hours
See the website of Fabrizia Grepioni
See the website of Simona Fermani
SDGs
![Quality education](https://www.unibo.it/++resource++unibo.didattica/sdg/en/04.jpg?v=2)
![Climate Action](https://www.unibo.it/++resource++unibo.didattica/sdg/en/13.jpg?v=2)
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.