84923 - Pharmacology and Pharmacotherapy II

Learning outcomes

At the end of the course the student: - knows the main molecular mechanisms and the pharmacodynamic and therapeutic profile of drugs active on the central nervous system, on renal and cardiovascular functions, on respiratory and gastro-intestinal functions, on inflammation and the immune system, on blood cells and on the coagulation and aggregation of platelets, minerals and vitamins; - knows the drugs that influence endocrine functions; - is able to evaluate the effectiveness and safety of drugs and their ability to prevent and treat certain diseases or alleviate their symptoms; - knows the main adverse and side effects that can limit its use; - is able to recognize interactions between drugs; - applies the knowledge learned to carry out the profession, for the correct storage and dispensing of medicines, to inform and educate on the use of medicines; - has the knowledge that allows him to report adverse reactions to drugs; - applies the knowledge learned to carry out the profession, for the correct storage and dispensing of medicines, to inform and educate on the use of medicines and monitor the management of the appropriateness in the use of medicines and the continuity of adherence to pharmacological therapy in chronic therapies.

Course contents

MODULE I -  Prof. Monica Baiula

INFLAMMATION PHARMACOLOGY: Introduction to immune system and inflammation. Hystamin, bradykinin and their antagonists. Lipid-derived autacoids: eicosanoids and PAF. NSAIDs. Glucocorticoids. Pharmacotherapy of gout. Immunosuppressants and tolerogens. Pharmacotherapy of rheumatoid arthritis.

PULMONARY PHARMACOLOGY AND PHARMACOTHERAPY: Pharmacotherapy of asthma and COPD. Antitussive and mucolytic drugs.

PHARMACOLOGY OF BLOOD FUNCTIONS: Hematopoietic agents. Treatment of anemia and blood disorders. Hypolipidemic drugs.

PHARMACOLOGY OF HEMOSTASIS: Anticoagulants. Thrombolytics. Antiplatelet drugs. Fibrinolytics and antifibrinolytics.

OCULAR PHARMACOLOGY: Pharmacotherapy of glaucoma. Pharmacotherapy of AMD and diabetes-induced macular edema.

HORMONS, HORMON ANTAGONISTS, ENDOCRINE PHARMACOLOGY: Hypothalmic and pituitary hormons. Estrogens, progestins, androgens and related antagonists. Endocrine pancreas and pharmacotherapy of diabetes. Hypoglycemic drugs. Modulation of feeding and energetic metabolism. Agents affecting mineral ion homeostasis and bone turnover. Thyroid and anti-thyroid drugs.

Module II Prof.ssa Patrizia Romualdi

Central nervous system- Organization of CNS

Opioid Analgesics: agonists and antagonists

Non Opiopid Analgesics: Paracetamol, Cannabinoids

General Anaesthetics

 Antiepilectics

Antidepressants

Drugs used in the treatment of psychoses

Ansiolitics,  Drug of abuse ,NPS (Neuropsychoactive compounds)

Treatment of central nervous system degenerative disorders: Drugs for Parkinson disease, AlzheimerDisease, Multiple Sclerosis, SLA

Cardiovascular and renal system
Drugs for the treatment of cardiac insufficiency and of  myocardial ischemia
Antiarrhythmic drugs, antiangina
Renin and angiotensin
Antihypertensive agents and the drug therapy of hypertension
Diuretics, Vasodilatators

Drugs affecting gastrointestinal function
Agent for ulcers
Agents used for control of gastric acidity and peptic ulcers

Readings/Bibliography

S. GOVONI, FARMACOLOGIA con sito web, Casa Ed. Ambrosiana I ed. italiana, Milano, 2022

B.G . KATZUNG, Farmacologia Generale e Clinica , Piccin . IX Edizione italiana sulla XII in lingua inglese, Piccin , 2018.

Goodman and Gilman " La basi farmacologiche della Terapia " XII ed . it . Zanichelli 2017.

 

 

 

Readings/Bibliography

Stefano Govoni, Santi Mario Spampinato, Pierluigi Navarra et al. Farmacologia s2nd edition. Casa Editrice Ambrosiana, 2024.

Goodman & Gilman. Le basi farmacologiche della terapia. Con espansione online Autori: Laurence L. Brunton, Randa Hilal-Dandan, Bjorn C. Knollmann Casa editrice Zanichelli - Edizione 2019.

B.G . KATZUNG, Farmacologia Generale e Clinica , Piccin . IX Edizione italiana sulla XII in linguainglese, Piccin , 2019.

RANG , DALE, RITTER, Farmacologia , VII Edizione, Elsevier , 2021.

Teaching methods

 Frontal lessons with Slides in Power Point available on Virtuale.

Assessment methods

MODULE I

The exam consists of two parts:

-firstly, a 60-minute-long written exam made of 5 open questions on all the topics included in the course program;

-Secondly, an oral exam for students who pass the written exam. The minimum score on the written test to qualify for the oral exam is 18/30. Students will be asked 2 questions on all topics covered in the course program.

Students must enroll for exams through AlmaEsami. The results of the written tests will be posted on Virtuale. If a student fails the oral test, they will need to retake both the written and oral exams.

 

MODULE 2

 

Teaching tools

Slides are displayed during classes and are available on Virtuale, accessible using Unibo credentials.

Office hours

See the website of Patrizia Romualdi

See the website of Monica Baiula