93307 - PATOLOGIA MOLECOLARE E DIAGNOSTICA

Academic Year 2025/2026

  • Moduli: Michelangelo Fiorentino (Modulo 1) Claudio Agostinelli (Modulo 2)
  • Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
  • Campus: Bologna
  • Corso: First cycle degree programme (L) in Biotechnology (cod. 5976)

Learning outcomes

The course aims to provide the basic elements of the molecular bases and of the main diagnostic molecular tests in human solid tumors. At the end of the course the student will be confident of the basic knowledge on the epidemiology, the histological diagnosis and the interpretation of molecular pathology tests.

Course contents

The course aims to provide the students with the basic elements of diagnostic molecular pathology, with particular focus on solid and hematologic tumors.

At the end of the course the student will learn the molecular bases of the main human tumors and the theory and the interpretation of the main techniques of diagnostic molecular pathology.

Program/Contents
  • Basic histopathology.
  • Techniques in histopathology.
  • Fundamentals of molecular diagnostics: in vitro techniques.
  • Fundamentals of molecular diagnostics: in situ techniques.
  • Immunohistochemistry.
  • Fluorescent and chromogenic in situ hibridization.
  • PCR/Real time PCR
  • Direct sequencing
  • NGS sequencing
  • Molecular tests predictive of response in personalized oncological medicine.
  • Focus on solid tumors.
  • Focus on tumors: ematological malignacies (leukemia and lymphomas)

Readings/Bibliography

Class presentations available on the Virtuale platform.

Teaching methods

Lectures.

Assessment methods

The final exam consists of a written test with 30 multiple choice questions on the matter of the presentations.
For each question, the student receives a vote. The weighted result based on the median performance of the other students and the standard deviation is expressed in 30/30.

The student who provides 30 correct answers obtains the vote of 30/30 cum laude

Teaching tools

Digitalized histological slides

Office hours

See the website of Michelangelo Fiorentino

See the website of Claudio Agostinelli