- Docente: Stefano Masiero
- Credits: 4
- SSD: CHIM/06
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
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Corso:
Single cycle degree programme (LMCU) in
Pharmaceutical Chemistry and Technology (cod. 5986)
Also valid for Single cycle degree programme (LMCU) in Pharmaceutical Chemistry and Technology (cod. 5986)
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from Oct 03, 2024 to Dec 12, 2024
Learning outcomes
The main goal of the course is to provide the student with both theoretical and practical backgrounds on: symmetry, molecular chirality and related concepts; main instrumental techniques for stereochemical characterization of organic molecules, biopolymers and supramolecular systems (circular dichroism, NMR, chromatographic methods, nematic liquid crystals, polarimetry, X ray diffraction); methods for the preparation of enantiopure compounds and techniques for the determination of optical purity and absolute configuration. At the end of the course the student achieves a deep understanding of organic stereochemistry and can autonomously perform research in the field.
Course contents
1) The molecular symmetry
2) Chirality and stereogenicity. Topicity relationships
3) Stereogenic units. Prochirality e prostereogenicity
4) Configuration descriptors
5) Physical manifestation of chirality. The role of chirality in biological systems
6) Stereoisomeric enrichment: resolutions and stereoselective transformations
7) Determination of the enantiomeric excess (Polarimetry, NMR, cromatographic methods)
8) Determination of relative and absolute configuration (Chemical correlation, X-ray diffraction, HPLC, NMR, Circular dichroism, Liquid crystal methods)
9) Special topics derived from recent literature
Readings/Bibliography
E.L. Eliel, S.H. Wilen, "Stereochemistry of Organic Compounds" Wiley Interscience, 1994
Teaching methods
Lectures.
Assessment methods
The final examination, aiming at ascertaining the student's acquired skills, consists of an oral presentation in front of classmates, pertaining a specific topic related to the course main contents. The subject will be agreed between student and teacher, who will provide the relevant literature. The presentation will be followed by a brief discussion.
Teaching tools
Presentations. Files of presentations will be available for download.
Office hours
See the website of Stefano Masiero