Learning outcomes
Knowledge of the physical, chemical, biological and engineering properties of Biomaterials.
Specific applications of Biomaterials in various bio-medical fields.
Characterization of Biomaterials.
Course contents
Introduction and Definitions
Panorama of general applications of biomaterials
Elements of Design of Biomaterials
Definition of Biocompatibility
The Frontier of Research: biomimetic materials and tissue engineering
Body reaction and response to material implantation
Introduction
Elements of Biology
The tissue healing process
Tissue response to material implantation
Blood response, hemocompatibility
Structure and properties of materials
The solid state and chemical bonds in solids
The definition of phase
Basics of thermodynamics and phase stability
Principles of crystallography
Order-disorder transitions
Defects in solids
Structure-property relationships
Structural and analytical methodologies for the characterization of biomaterials
Mechanical properties
Hardness, friction, wear
Thermal, electrical and acoustic properties
X-ray absorption, density and porosity
Bone, enamel and dentine permeability
Optical properties
Metallic Biomaterials
Structure and properties of metals
Phase diagrams
Stainless steels, CoCr, Titanium alloys, gold and noble metal alloys, NiTi, and Shape Memory Alloys
Application of metals
Biocorrosion, Pourbaix diagrams
Production processes
Ceramic Biomaterials
Structure and properties of ceramics
Bioinert, biodegradable and bioactive ceramics
Application of ceramics
Carbon
Production processes
Biominerals
Biological tissues
Human hard tissues
Hydroxyapatites
Human soft tissues
Collagen and elastin
Tissue-derived biomaterials
Preparation procedures
Synthetic polymers
The polymerization processes
Structure and texture of polymers
Glass transition
Thermoplastic and thermohardening polymers
Structure property relationships
Biocompatibility
Production processes
Composite biomaterials
Prostheses
Biocompatibility tests
Regulation and trading of biomaterials
Readings/Bibliography
REFERENCE BOOKS AND READING
C.Di Bello, Biomateriali, Pàtron Editore, Bologna
R.Pietrabissa, Biomateriali per protesi e organi artificiali, Pàtron Editore, Bologna
G.Valdrè, U.Valdrè, Misure e complementi di fisica, CLUEB, Bologna
A.F.von Recum, Handbook of Biomaterials Evaluation, Taylor & Francis, London
Readings/Bibliography
C.Di Bello, Biomateriali, Pàtron Editore, Bologna
R.Pietrabissa, Biomateriali per protesi e organi artificiali, Pàtron Editore, Bologna
G.Valdrè, U.Valdrè, Misure e complementi di fisica, CLUEB, Bologna
A.F.von Recum, Handbook of Biomaterials Evaluation, Taylor & Francis, London
G.Valdrè - Slides and Notes on Biomaterials
Teaching methods
Propedeutic and pedagogical approach.
Assessment methods
Oral Examination
Teaching tools
Examples and Seminars
Office hours
See the website of
Giovanni Valdrè
See the website of
Silvano Zanna
