- Docente: Sandro Grilli
- Credits: 2
- SSD: MED/04
- Language: Italian
- Teaching Mode: In-person learning (entirely or partially)
- Campus: Bologna
- Corso: First cycle degree programme (L) in Environment and Workplace Prevention Techniques (cod. 8487)
Learning outcomes
At the end of the course the student is able to known the main pathogenetic mechanisms which are responsible of main pathologies.
Course contents
Main subjects:
- selected online websites for scientific evaluations
- general principles of pathology and environment - humans interaction (environment and health): neoplasia, cardiovascular, respiratory, especially related to noted pollutants (e.g. PM10 and PM2,5), and musculoskeletal (teratogenesis, osteoporosis) diseases. Blockage of neuromuscular synapsis. Cell damage, inflammation, immune response, cardio-vascular diseases.
- mutagenesis, carcinogenesis and chemoprevention from the point of view of primary prevention. Tumor classification and phenotype.
- human effects, either in working sites and in normal environment, induced by contaminations of biological matrices (food, air) by heavy metals, benzene, organochlorine chemicals in drinking water, asbestos, pesticides, with particular emphasis on cancer risk. Effects of ionizing and non-ionizing radiations. Main diseases associated to tobacco smoke and diet. Endocrine interfent agents.
- methodology of cancer risk assessment (epidemiologic and/or animal data) with the aid of informatics and practices with the models available to assess cancer risk unit and its application to different (relevant or not relevant) exposure scenarios both in normal life environment and in occupational activities.
Readings/Bibliography
At the beginning of the integrated course (I.C.), students will receive indication on updated didactic materials produced in electronic format by other professors teaching General pathology (MED/04) in different graduate courses. These materials are stored on AMS Campus AlmaDL University of Bologna website: http://campus.unibo.it/. Username and password are those given to each student of the University of Bologna. This link to other professors of general pathology warrants maximal coherence between didactics performed in the triennial graduate courses.
Moreover, ad hoc software programs will be made available
Teaching methods
Ex-cathedra lessons and practices both on computers and, outside and extra time, on potable (trihalomethanes) and waste (hexavalent chromium) waters and on environmental background radioactivity and radioprotection.
Assessment methods
Oral final examination aims to evacuate achieving of didactic objectives and therefore the main knowledge as to general pathology:
- Molecular pathology
- Cellular pathology
- tissue pathology
- organ diseases
with particular emphasis on toxic and pathological effects like: fertility, reproduction, mutagenesis and carcinogenesis by chemical, physical and biological agents.
Final vote takes into account the synthesis of final evaluations of different subjects belonging to the I.C. of Preventive Sciences III. Each single evaluation is integrated in order to obtain the unique final vote (max performance 30 points). Such vote is the average of votes obtained on specific questions on subjects and main objectives of the I.C. Examination is passed if votes in each subjects are not lower than 18 points.
Teaching tools
Video (multimedial) and overhead projectors, computers and softwares. For slides, see AMS Campus.
Office hours
See the website of Sandro Grilli